Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats

المؤلفون المشاركون

Yu, Chung-Ping
Shia, Chi-Sheng
Tsai, Shang-Yuan
Hou, Yu-Chi

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-11-01

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Gegen-Qinlian-Tang (GQT), a popular Chinese medicine prescription, consists of Puerariae Radix, Scutellariae Radix, Coptidis Rhizoma, and Glycyrrhizae Radix.

This study investigated the pharmacokinetics of GQT in rats and compared the bioavailability between two dosage forms, that is, traditional decoction (TD) and concentrated powder (CP).

Rats were given TD and CP of GQT in a crossover design, and blood samples were withdrawn at predetermined time points.

The quantitation methods of ten constituents in two dosage forms of GQT and in serum specimen using HPLC were developed and validated in this study.

The pharmacokinetic parameters were calculated using noncompartment model.

The results showed that daidzein, baicalein, wogonin, berberine, palmatine, and coptisine were not found in the circulation, whereas the sulfates/glucuronides of daidzein, baicalein, and wogonin were the major forms after oral administration of GQT.

Comparison between two dosage forms indicated that the AUC0–t of daidzein sulfates/glucuronides after administration of CP was significantly lower than that of TD by 28.9%, whereas the bioavailabilities of baicalin/baicalein and wogonoside/wogonin were comparable between two dosage forms.

In conclusion, the major flavonoids of GQT were extensively metabolized into sulfates/glucuronides and present as the major molecules in the circulation.

TD of GQT revealed higher bioavailability of daidzin/daidzein than CP.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yu, Chung-Ping& Shia, Chi-Sheng& Tsai, Shang-Yuan& Hou, Yu-Chi. 2012. Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992188

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yu, Chung-Ping…[et al.]. Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992188

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yu, Chung-Ping& Shia, Chi-Sheng& Tsai, Shang-Yuan& Hou, Yu-Chi. Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992188

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-992188