Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice

الملخص EN

Ecklonia cava (E.

cava) is a brown alga that has beneficial effects in models of type 1 and type 2 diabetes.

However, the effects of E.

cava extracts on diet-induced obesity and type 2 diabetes have not been specifically examined.

We investigated the effects of E.

cava on body weight, fat content, and hyperglycemia in high-fat diet- (HFD) induced obese mice and sought the mechanisms involved.

C57BL/6 male mice were fed a HFD (60% fat) diet or normal chow.

After 3 weeks, the HFD diet group was given extracts (200 mg/kg) of E.

cava harvested from Jeju (CA) or Gijang (G-CA), Korea or PBS by oral intubation for 8 weeks.

Body weights were measured weekly.

Blood glucose and glucose tolerance were measured at 7 weeks, and fat pad content and mRNA expression of adipogenic genes and inflammatory cytokines were measured after 8 weeks of treatment.

G-CA was effective in reducing body weight gain, body fat, and hyperglycemia and improving glucose tolerance as compared with PBS-HFD mice.

The mRNA expression of adipogenic genes was increased, and mRNA expression of inflammatory cytokines and macrophage marker gene was decreased in G-CA-treated obese mice.

We suggest that G-CA reduces obesity and glucose levels by anti-inflammatory actions and improvement of lipid metabolism.