Antidiabetic Effect of an Active Components Group from Ilex kudingcha and Its Chemical Composition
المؤلفون المشاركون
Song, Chengwu
Xie, Chao
Zhou, Zhiwen
Yu, Shanggong
Fang, Nianbai
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The leaves of Ilex kudingcha are used as an ethnomedicine in the treatment of symptoms related with diabetes mellitus and obesity throughout the centuries in China.
The present study investigated the antidiabetic activities of an active components group (ACG) obtained from Ilex kudingcha in alloxan-induced type 2 diabetic mice.
ACG significantly reduced the elevated levels of serum glycaemic and lipids in type 2 diabetic mice.
3-Hydroxy-3-methylglutaryl coenzyme A reductase and glucokinase were upregulated significantly, while fatty acid synthetase, glucose-6-phosphatase catalytic enzyme was downregulated in diabetic mice after treatment of ACG.
These findings clearly provided evidences regarding the antidiabetic potentials of ACG from Ilex kudingcha.
Using LC-DAD/HR-ESI-TOF-MS, six major components were identified in ACG.
They are three dicaffeoylquinic acids that have been reported previously, and three new triterpenoid saponins, which were the first time to be identified in Ilex kudingcha.
It is reasonable to assume that antidiabetic activity of Ilex kudingcha against hyperglycemia resulted from these six major components.
Also, synergistic effects among their compounds may exist in the antidiabetic activity of Ilex kudingcha.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Chengwu& Xie, Chao& Zhou, Zhiwen& Yu, Shanggong& Fang, Nianbai. 2012. Antidiabetic Effect of an Active Components Group from Ilex kudingcha and Its Chemical Composition. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992272
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Chengwu…[et al.]. Antidiabetic Effect of an Active Components Group from Ilex kudingcha and Its Chemical Composition. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992272
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Chengwu& Xie, Chao& Zhou, Zhiwen& Yu, Shanggong& Fang, Nianbai. Antidiabetic Effect of an Active Components Group from Ilex kudingcha and Its Chemical Composition. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992272
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992272
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر