Fermented Mistletoe Extract as a Multimodal Antitumoral Agent in Gliomas
المؤلفون المشاركون
Podlech, Oliver
Harter, Patrick N.
Mittelbronn, Michel
Pöschel, Simone
Naumann, Ulrike
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-22
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
In Europe, commercially available extracts from the white-berry mistletoe (Viscum album L.) are widely used as a complementary cancer therapy.
Mistletoe lectins have been identified as main active components and exhibit cytotoxic effects as well as immunomodulatory activity.
Since it is still not elucidated in detail how mistle toe extracts such as ISCADOR communicate their effects, we analyzed the mechanisms that might be responsible for their antitumoral function on a molecular and functional level.
ISCADOR-treated glioblastoma (GBM) cells down-regulate central genes involved in glioblastoma progression and malignancy such as the cytokine TGF-β and matrix-metalloproteinases.
Using in vitro glioblastoma/immune cell co-cultivation assays as well as measurement of cell migration and invasion, we could demonstrate that in glioblastoma cells, lectin-rich ISCADOR M and ISCADOR Q significantly enforce NK-cell-mediated GBM cell lysis.
Beside its immune stimulatory effect, ISCADOR reduces the migratory and invasive potential of glioblastoma cells.
In a syngeneic as well as in a xenograft glioblastoma mouse model, both pretreatment of tumor cells and intratumoral therapy of subcutaneously growing glioblastoma cells with ISCADOR Q showed delayed tumor growth.
In conclusion, ISCADOR Q, showing multiple positive effects in the treatment of glioblastoma, may be a candidate for concomitant treatment of this cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Podlech, Oliver& Harter, Patrick N.& Mittelbronn, Michel& Pöschel, Simone& Naumann, Ulrike. 2012. Fermented Mistletoe Extract as a Multimodal Antitumoral Agent in Gliomas. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-992353
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Podlech, Oliver…[et al.]. Fermented Mistletoe Extract as a Multimodal Antitumoral Agent in Gliomas. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-992353
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Podlech, Oliver& Harter, Patrick N.& Mittelbronn, Michel& Pöschel, Simone& Naumann, Ulrike. Fermented Mistletoe Extract as a Multimodal Antitumoral Agent in Gliomas. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-992353
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992353
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر