![](/images/graphics-bg.png)
Cinnamomi ramulus Ethanol Extract Exerts Vasorelaxation through Inhibition of Ca2+ Influx and Ca2+ Release in Rat Aorta
المؤلفون المشاركون
Kang, Yun Hwan
Shin, Heung-Mook
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Contraction of vascular smooth muscle cells depends on the induction of cytosolic calcium ion (Ca2+) due to either Ca2+ influx through voltage-gated Ca2+ channels or to receptor-mediated Ca2+ release from the sarcoplasmic reticulum.
The present study investigated the vasorelaxation effect of Cinnamomi ramulus ethanol extract (CRE) and the possible mechanisms in rat aorta.
CRE (0.1 mg/mL) relaxed vasoconstriction induced by phenylephrine (PE; 1 μM) and angiotensin II (5 μM).
Preincubation with CRE significantly reduced the rat aortic contraction by addition of CaCl2 in Ca2+-free Krebs solution and FPL64176 (10 μM).
Pretreatment with nifedipine (100 μM) or verapamil (1 μM) significantly reduced the CRE-mediated vasorelaxation of PE-induced vascular contraction.
In addition, CRE also relaxed the vascular contraction caused by m-3M3FBS (5 μg/mL), but U73122 (10 μM) significantly inhibited the vasorelaxation of PE precontracted aortic rings.
Furthermore, CRE significantly reduced the magnitude of PE- and caffeine (30 mM)-induced transient contraction.
In vascular strips, CRE downregulated the expression levels of phosphorylated PLC and phosphoinositide 3-kinase elevated by PE or m-3M3FBS.
These results suggest that CRE relaxes vascular smooth muscle through the inhibition of both Ca2+ influx via L-type Ca2+ channel and inositol triphosphate-induced Ca2+ release from the sarcoplasmic reticulum.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kang, Yun Hwan& Shin, Heung-Mook. 2012. Cinnamomi ramulus Ethanol Extract Exerts Vasorelaxation through Inhibition of Ca2+ Influx and Ca2+ Release in Rat Aorta. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kang, Yun Hwan& Shin, Heung-Mook. Cinnamomi ramulus Ethanol Extract Exerts Vasorelaxation through Inhibition of Ca2+ Influx and Ca2+ Release in Rat Aorta. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kang, Yun Hwan& Shin, Heung-Mook. Cinnamomi ramulus Ethanol Extract Exerts Vasorelaxation through Inhibition of Ca2+ Influx and Ca2+ Release in Rat Aorta. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)