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Terminalia catappa Exerts Antimetastatic Effects on Hepatocellular Carcinoma through Transcriptional Inhibition of Matrix Metalloproteinase-9 by Modulating NF-κB and AP-1 Activity
المؤلفون المشاركون
Lin, Pen-Yuan
Hsieh, Yih-Shou
Yeh, Chao-Bin
Chiou, Hui-Ling
Yang, Shun-Fa
Chien, Ming-Hsien
Hsieh, Ming-Ju
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
High mortality and morbidity rates for hepatocellular carcinoma (HCC) in Taiwan primarily result from uncontrolled tumor metastasis.
Previous studies have identified that Terminalia catappa leaf extracts (TCE) exert hepatoprotective, antioxidative, antiinflammatory, anticancer, and antimetastatic activities.
However, the effects of TCE on HCC and the underlying molecular mechanisms of its activities have yet to be fully elucidated.
The present study's findings demonstrate that TCE concentration dependently inhibits human HCC migration/invasion.
Zymographic and western blot analyses revealed that TCE inhibited the activities and expression of matrix metalloproteinase-9 (MMP-9).
Assessment of mRNA levels, using reverse transcriptase polymerase chain reaction (PCR) and real-time PCR, and promoter assays confirmed the inhibitory effects of TCE on MMP-9 expression in HCC cells.
The inhibitory effects of TCE on MMP-9 proceeded by upregulating tissue inhibitor of metalloproteinase-1 (TIMP-1), as well as suppressing nuclear translocation and DNA binding activity of nuclear factor-kappa B (NF-κB) and activating protein-1 (AP-1) on the MMP-9 promoter in Huh7 cells.
In conclusion, TCE inhibits MMP-9 expression and HCC cell metastasis and, thus, has potential use as a chemopreventive agent.
Its inhibitory effects are associated with downregulation of the binding activities of the transcription factors NF-κB and AP-1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yeh, Chao-Bin& Hsieh, Ming-Ju& Hsieh, Yih-Shou& Chien, Ming-Hsien& Lin, Pen-Yuan& Chiou, Hui-Ling…[et al.]. 2012. Terminalia catappa Exerts Antimetastatic Effects on Hepatocellular Carcinoma through Transcriptional Inhibition of Matrix Metalloproteinase-9 by Modulating NF-κB and AP-1 Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992438
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yeh, Chao-Bin…[et al.]. Terminalia catappa Exerts Antimetastatic Effects on Hepatocellular Carcinoma through Transcriptional Inhibition of Matrix Metalloproteinase-9 by Modulating NF-κB and AP-1 Activity. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-992438
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yeh, Chao-Bin& Hsieh, Ming-Ju& Hsieh, Yih-Shou& Chien, Ming-Hsien& Lin, Pen-Yuan& Chiou, Hui-Ling…[et al.]. Terminalia catappa Exerts Antimetastatic Effects on Hepatocellular Carcinoma through Transcriptional Inhibition of Matrix Metalloproteinase-9 by Modulating NF-κB and AP-1 Activity. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992438
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992438
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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