Ethnopharmacokinetic- and Activity-Guided Isolation of a New Antidepressive Compound from Fructus Aurantii Found in the Traditional Chinese Medicine Chaihu-Shugan-San: A New Approach and Its Application
المؤلفون المشاركون
Fan, Rong
Huang, Xi
Wang, Yang
Chen, Xiao
Ren, Ping
Ji, Hui
Xie, Ying
Zhang, Yingjin
Huang, Wei
Qiu, Xinjian
Liu, Zhaoqian
Zhou, Honghao
Fan, Lan
Gao, Lichen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
We aimed to identify an antidepressive compound found in traditional Chinese medicine (TCM) by a new approach called ethnopharmacokinetic- and activity-guided isolation (EAGI).
Methods.
The new approach targets an unknown chromatographic peak produced by an absorbed compound found in oral Chaihu-Shugan-San (CSS) taken by patients with depression.
Once the compound was isolated from Fructus Aurantii (FA), spectral data was employed to identify the compound.
The effects of this compound, FA, and CSS on depressive behaviors were investigated.
Results.
The identified compound was merazin hydrate (MH) according to the new approach.
MH, FA, and CSS significantly reduced immobility time and increased locomotor activity.
The effects of MH, FA and CSS were similar to Fluoxetine at high doses.
Conclusion.
MH, a compound whose antidepressive effect is similar to FA and CSS, was isolated for the first time from FA via targeting its corresponding unknown chromatographic peak, and its antidepressive effect was compared with FA or CSS.
These findings highlight the potential for drug R&D and pharmacological research of ~100,000 TCMs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Rong& Huang, Xi& Wang, Yang& Chen, Xiao& Ren, Ping& Ji, Hui…[et al.]. 2012. Ethnopharmacokinetic- and Activity-Guided Isolation of a New Antidepressive Compound from Fructus Aurantii Found in the Traditional Chinese Medicine Chaihu-Shugan-San: A New Approach and Its Application. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992455
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Rong…[et al.]. Ethnopharmacokinetic- and Activity-Guided Isolation of a New Antidepressive Compound from Fructus Aurantii Found in the Traditional Chinese Medicine Chaihu-Shugan-San: A New Approach and Its Application. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992455
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Rong& Huang, Xi& Wang, Yang& Chen, Xiao& Ren, Ping& Ji, Hui…[et al.]. Ethnopharmacokinetic- and Activity-Guided Isolation of a New Antidepressive Compound from Fructus Aurantii Found in the Traditional Chinese Medicine Chaihu-Shugan-San: A New Approach and Its Application. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992455
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992455
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر