Mechanism of Earthquake Simulation as a Prenatal Stressor Retarding Rat Offspring Development and Chinese Medicine Correcting the Retardation: Hormones and Gene-Expression Alteration
المؤلفون المشاركون
Zhang, X. G.
Zhang, H.
Tan, R.
Peng, J. C.
Liang, X. L.
Liu, Q.
Wang, M. Q.
Yu, X. P.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-26
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
We aimed to investigate the mechanism of shaking as a prenatal stressor impacting the development of the offspring and Chinese medicines correcting the alterations.
Pregnant rats were randomized into earthquake simulation group (ESG), herbal group (HG) which received herbal supplements in feed after shaking, and control group (CG).
Findings revealed body weight and open field test (OFT) score of ESG offspring were statistically inferior to the CG and HG offspring.
The corticosterone levels of ESG were higher than those of CG but not than HG.
The dopamine level of ESG was slightly lower than that of the CG and of HG was higher than that of ESG.
The 5-HT of ESG was higher than CG and HG.
The growth hormone level of the ESG was significantly lower than ESG but not than CG.
Gene expression profile showed 81 genes upregulated and 39 genes downregulated in ESG versus CG, and 60 genes upregulated and 28 genes downregulated in ESG versus HG.
Eighty-four genes were found differentially expressed in ESG versus CG comparison and were normalized in ESG versus HG.
We conclude that maternal shaking negatively affected physical and nervous system development, with specific alterations in neurohormones and gene expression.
Chinese herbal medicine reduced these negative outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, X. G.& Zhang, H.& Tan, R.& Peng, J. C.& Liang, X. L.& Liu, Q.…[et al.]. 2012. Mechanism of Earthquake Simulation as a Prenatal Stressor Retarding Rat Offspring Development and Chinese Medicine Correcting the Retardation: Hormones and Gene-Expression Alteration. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-992514
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, X. G.…[et al.]. Mechanism of Earthquake Simulation as a Prenatal Stressor Retarding Rat Offspring Development and Chinese Medicine Correcting the Retardation: Hormones and Gene-Expression Alteration. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-992514
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, X. G.& Zhang, H.& Tan, R.& Peng, J. C.& Liang, X. L.& Liu, Q.…[et al.]. Mechanism of Earthquake Simulation as a Prenatal Stressor Retarding Rat Offspring Development and Chinese Medicine Correcting the Retardation: Hormones and Gene-Expression Alteration. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-992514
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992514
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر