Effects of Different Electroacupuncture Scheduling Regimens on Murine Bone Tumor-Induced Hyperalgesia: Sex Differences and Role of Inflammation
المؤلفون المشاركون
al-Gizawiy, Mona
Beitz, Alvin J.
Smeester, Branden A.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-20
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Previous studies have shown that electroacupuncture (EA) is able to reduce hyperalgesia in rodent models of persistent pain, but very little is known about the analgesic effects and potential sex differences of different EA treatment regimens.
In the present study, we examined the effects of five different EA treatments on tumor-induced hyperalgesia in male and female mice.
EA applied to the ST-36 acupoint either twice weekly (EA-2X/3) beginning on postimplantation day (PID) 3 or prophylactically three times prior to implantation produced the most robust and longest lasting antinociceptive effects.
EA treatment given once per week beginning at PID 7 only produced an antinociceptive effect in female animals.
The analgesic effect of EA-2X/3 began earlier in males, but lasted longer in females indicating sex differences in EA.
We further demonstrate that EA-2X/3 elicits a marked decrease in tumor-associated inflammation as evidenced by a significant reduction in tumor-associated neutrophils at PID 7.
Moreover, EA-2X/3 produced a significant reduction in tumor-associated PGE2 as measured in microperfusate samples.
Collectively, these data provide evidence that EA-2X/3 treatment reduces tumor-induced hyperalgesia, which is associated with a decrease in tumor-associated inflammation and PGE2 concentration at the tumor site suggesting possible mechanisms by which EA reduces tumor nociception.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Smeester, Branden A.& al-Gizawiy, Mona& Beitz, Alvin J.. 2012. Effects of Different Electroacupuncture Scheduling Regimens on Murine Bone Tumor-Induced Hyperalgesia: Sex Differences and Role of Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-992517
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Smeester, Branden A.…[et al.]. Effects of Different Electroacupuncture Scheduling Regimens on Murine Bone Tumor-Induced Hyperalgesia: Sex Differences and Role of Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-992517
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Smeester, Branden A.& al-Gizawiy, Mona& Beitz, Alvin J.. Effects of Different Electroacupuncture Scheduling Regimens on Murine Bone Tumor-Induced Hyperalgesia: Sex Differences and Role of Inflammation. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-992517
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992517
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر