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Protective Effects of Green Tea Extract against Hepatic Tissue Injury in Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Abolfathi, Ali Akbar
Mohajeri, Daryoush
Rezaie, Ali
Nazeri, Mehrdad
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Although diabetic hepatopathy is potentially less common, it may be appropriate for addition to the list of target organ conditions related to diabetes.
This study was designed to evaluate the hepatoprotective properties of green tea extract (GTE) in STZ-induced diabetes in rats.
Wistar rats were made diabetic through single injection of STZ (75 mg/kg i.p.).
The rats were randomly divided into four groups of 10 animals each: Group 1, healthy control; Group 2, nondiabetics treated with GTE administered orally (1.5%, w/v); Group 3, diabetics; Group 4, diabetics treated with GTE (1.5%, w/v) for 8 weeks.
Serum biomarkers were assessed to determine hepatic injury.
Malondialdehyde (MDA) and reduced glutathione (GSH) contents were measured to assess free radical activity in the liver tissue.
Hepatic antioxidant activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) were also determined.
The biochemical findings were matched with histopathological verifications.
Liver MDA content and serum levels of ALT, AST, ALP, and bilirubin in Group 3 significantly increased compared to Group 1 (P<0.05) and significantly decreased in Group 4 compared to Group 3 (P<0.05).
Serum albumin level and GSH, SOD, CAT, and GSH-Px contents of the liver in Group 3 were significantly decreased compared to Group 1 (P<0.05) and were significantly increased in Group 4 compared to Group 3 (P<0.05).
Histopathologically, the changes were in the same direction with biochemical findings.
This study proved the hepatoprotective activity of GTE in experimentally induced diabetic rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abolfathi, Ali Akbar& Mohajeri, Daryoush& Rezaie, Ali& Nazeri, Mehrdad. 2011. Protective Effects of Green Tea Extract against Hepatic Tissue Injury in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992603
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abolfathi, Ali Akbar…[et al.]. Protective Effects of Green Tea Extract against Hepatic Tissue Injury in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992603
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abolfathi, Ali Akbar& Mohajeri, Daryoush& Rezaie, Ali& Nazeri, Mehrdad. Protective Effects of Green Tea Extract against Hepatic Tissue Injury in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992603
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992603
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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