Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice
المؤلفون المشاركون
Perfumi, Marina
Mattioli, Laura
Titomanlio, Federica
Bracci, Antonio
De Feo, Vincenzo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The aim of the present study was to investigate, in vivo, the effect of a Brugmansia arborea extract (BRU), chromatographic fractions (FA and FNA), and isolated alkaloids on the expression and the acquisition of morphine tolerance and dependence.
Substances were acutely (for expression) or repeatedly (for acquisition) administered in mice treated with morphine twice daily for 5 or 6 days, in order to make them tolerant or dependent.
Morphine tolerance was assessed using the tail-flick test at 1st and 5th days.
Morphine dependence was evaluated through the manifestation of withdrawal symptoms induced by naloxone injection at 6th day.
Results showed that BRU significantly reduced the expression of morphine tolerance, while it was ineffective to modulate its acquisition.
Chromatographic fractions and pure alkaloids failed to reduce morphine tolerance.
Conversely BRU, FA, and pure alkaloids administrations significantly attenuated both development and expression of morphine dependence.
These data suggest that Brugmansia arborea Lagerh might have human therapeutic potential for treatment of opioid addiction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mattioli, Laura& Bracci, Antonio& Titomanlio, Federica& Perfumi, Marina& De Feo, Vincenzo. 2012. Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992607
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mattioli, Laura…[et al.]. Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992607
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mattioli, Laura& Bracci, Antonio& Titomanlio, Federica& Perfumi, Marina& De Feo, Vincenzo. Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992607
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992607
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر