Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models
المؤلفون المشاركون
Man, Mao-Qiang
Hupe, Melanie
Sun, Richard
Man, George
Mauro, Theodora M.
Elias, Peter M.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Herbal medicines have been used in preventing and treating skin disorders for centuries.
It has been demonstrated that systemic administration of chrysanthemum extract exhibits anti-inflammatory properties.
However, whether topical applications of apigenin, a constituent of chrysanthemum extract, influence cutaneous inflammation is still unclear.
In the present study, we first tested whether topical applications of apigenin alleviate cutaneous inflammation in murine models of acute dermatitis.
The murine models of acute allergic contact dermatitis and acute irritant contact dermatitis were established by topical application of oxazolone and phorbol 12-myristate 13-acetate (TPA), respectively.
Inflammation was assessed in both dermatitis models by measuring ear thickness.
Additionally, the effect of apigenin on stratum corneum function in a murine subacute allergic contact dermatitis model was assessed with an MPA5 physiology monitor.
Our results demonstrate that topical applications of apigenin exhibit therapeutic effects in both acute irritant contact dermatitis and allergic contact dermatitis models.
Moreover, in comparison with the vehicle treatment, topical apigenin treatment significantly reduced transepidermal water loss, lowered skin surface pH, and increased stratum corneum hydration in a subacute murine allergic contact dermatitis model.
Together, these results suggest that topical application of apigenin could provide an alternative regimen for the treatment of dermatitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Man, Mao-Qiang& Hupe, Melanie& Sun, Richard& Man, George& Mauro, Theodora M.& Elias, Peter M.. 2012. Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992766
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Man, Mao-Qiang…[et al.]. Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992766
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Man, Mao-Qiang& Hupe, Melanie& Sun, Richard& Man, George& Mauro, Theodora M.& Elias, Peter M.. Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992766
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992766
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر