Evolutionary Conservation and Diversification of the Translation Initiation Apparatus in Trypanosomatids
المؤلفون المشاركون
Shapira, Michal
Zinoviev, Alexandra
المصدر
International Journal of Genomics
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Trypanosomatids are ancient eukaryotic parasites that migrate between insect vectors and mammalian hosts, causing a range of diseases in humans and domestic animals.
Trypanosomatids feature a multitude of unusual molecular features, including polycistronic transcription and subsequent processing by trans-splicing and polyadenylation.
Regulation of protein coding genes is posttranscriptional and thus, translation regulation is fundamental for activating the developmental program of gene expression.
The spliced-leader RNA is attached to all mRNAs.
It contains an unusual hypermethylated cap-4 structure in its 5′ end.
The cap-binding complex, eIF4F, has gone through evolutionary changes in accordance with the requirement to bind cap-4.
The eIF4F components in trypanosomatids are highly diverged from their orthologs in higher eukaryotes, and their potential functions are discussed.
The cap-binding activity in all eukaryotes is a target for regulation and plays a similar role in trypanosomatids.
Recent studies revealed a novel eIF4E-interacting protein, involved in directing stage-specific and stress-induced translation pathways.
Translation regulation during stress also follows unusual regulatory cues, as the increased translation of Hsp83 following heat stress is driven by a defined element in the 3′ UTR, unlike higher eukaryotes.
Overall, the environmental switches experienced by trypanosomatids during their life cycle seem to affect their translational machinery in unique ways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zinoviev, Alexandra& Shapira, Michal. 2012. Evolutionary Conservation and Diversification of the Translation Initiation Apparatus in Trypanosomatids. International Journal of Genomics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992921
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zinoviev, Alexandra& Shapira, Michal. Evolutionary Conservation and Diversification of the Translation Initiation Apparatus in Trypanosomatids. International Journal of Genomics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992921
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zinoviev, Alexandra& Shapira, Michal. Evolutionary Conservation and Diversification of the Translation Initiation Apparatus in Trypanosomatids. International Journal of Genomics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992921
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992921
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر