Severe Maternal Hyperglycemia Exacerbates the Development of Insulin Resistance and Fatty Liver in the Offspring on High Fat Diet
المؤلفون المشاركون
Zhao, Yong
Yu, Chao
Li, Jibin
Li, Jingna
Xiao, Xiaoqiu
Song, Yong
Liu, Zhiguo
Chen, Xiaoyi
Zhang, Qijuan
Yang, Zhu
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Adverse maternal environments may predispose the offspring to metabolic syndrome in adulthoods, but the underlying mechanism has not been fully understood.
Methods.
Maternal hyperglycemia was induced by streptozotocin (STZ) injection while control (CON) rats received citrate buffer.
Litters were adjusted to eight pups per dam and then weaned to standard diet.
Since 13 weeks old, a subset of offspring from STZ and CON dams were switched to high fat diet (HFD) for another 13 weeks.
Glucose and insulin tolerance tests (GTT and ITT) and insulin secretion assay were performed; serum levels of lipids and leptin were measured.
Hepatic fat accumulation and islet area were evaluated through haematoxylin and eosin staining.
Results.
STZ offspring exhibited lower survival rate, lower birth weights, and growth inhibition which persisted throughout the study.
STZ offspring on HFD showed more severe impairment in GTT and ITT, and more profound hepatic steatosis and more severe hyperlipidemia compared with CON-HFD rats.
Conclusions.
Offspring from diabetic dams would be prone to exhibit low birth weight and postnatal growth inhibition, but could maintain normal glucose tolerance and insulin sensitivity.
HFD accelerates development of insulin resistance in the offspring of diabetic dams mainly via a compensatory response of islets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Yong& Li, Jibin& Zhao, Yong& Zhang, Qijuan& Liu, Zhiguo& Li, Jingna…[et al.]. 2012. Severe Maternal Hyperglycemia Exacerbates the Development of Insulin Resistance and Fatty Liver in the Offspring on High Fat Diet. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-993952
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Yong…[et al.]. Severe Maternal Hyperglycemia Exacerbates the Development of Insulin Resistance and Fatty Liver in the Offspring on High Fat Diet. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-993952
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Yong& Li, Jibin& Zhao, Yong& Zhang, Qijuan& Liu, Zhiguo& Li, Jingna…[et al.]. Severe Maternal Hyperglycemia Exacerbates the Development of Insulin Resistance and Fatty Liver in the Offspring on High Fat Diet. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-993952
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-993952
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر