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Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency
المؤلفون المشاركون
Matsumoto, Kozo
Kose, Hiroyuki
Yamada, Takahisa
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-05
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Obesity has been considered one of the leading causative agents for diseases such as type 2 diabetes, stroke, and heart attack.
Due to their complex etiology, establishing auseful animal model is increasingly crucial for better molecular understanding of how obesity influences on disease development.
OLETF rat is a spontaneous model of type 2 diabetes.
We mapped 14 hyperglycemia QTLs in the genome of the OLETF rat and subsequently generated a panel of congenic strains each possessing OB-R mutation in F344 genetic background.
Here we show that one of the loci, Nidd2/of, is highly responsive to obesity.
When leptin receptor mutation is introgressed into the Nidd2/of congenic strain, the rat showed hyperglycemia equivalent to that of the parental OLETF rat.
This suggests that the Nidd2/of locus has a strong genetic interaction with leptin signaling pathway.
Furthermore, when another hyperglycemia QTL Nidd1/of is additionally combined, the strain developed overt diabetes.
A single QTL dissected out in spontaneous model normally exerts only mild effect on the quantitative trait, which makes it difficult to clone the gene.
Our new model may help not only to identify the causative gene but also to investigate how obesity interacts with a QTL to regulate diabetic traits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kose, Hiroyuki& Yamada, Takahisa& Matsumoto, Kozo. 2012. Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994101
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kose, Hiroyuki…[et al.]. Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-994101
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kose, Hiroyuki& Yamada, Takahisa& Matsumoto, Kozo. Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994101
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-994101
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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