Towards Curative Cancer Immunotherapy: Overcoming Posttherapy Tumor Escape
المؤلفون المشاركون
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The past decade has witnessed the evolvement of cancer immunotherapy as an increasingly effective therapeutic modality, evidenced by the approval of two immune-based products by the FDA, that is, the cancer vaccine Provenge (sipuleucel-T) for prostate cancer and the antagonist antibody against cytotoxic T-lymphocyte antigen-4 (CTLA-4) ipilimumab for advanced melanoma.
In addition, the clinical evaluations of a variety of promising immunotherapy drugs are well under way.
Benefiting from more efficacious immunotherapeutic agents and treatment strategies, a number of recent clinical studies have achieved unprecedented therapeutic outcomes in some patients with certain types of cancers.
Despite these advances, however, the efficacy of most cancer immunotherapies currently under clinical development has been modest.
A recurring scenario is that therapeutic maneuvers initially led to measurable antitumor immune responses in cancer patients but ultimately failed to improve patient outcomes.
It is increasingly recognized that tumor cells can antagonize therapy-induced immune attacks through a variety of counterregulation mechanisms, which represent a fundamental barrier to the success of cancer immunotherapy.
Herein we summarize the findings from some recent preclinical and clinical studies, focusing on how tumor cells advance their survival and expansion by hijacking therapy-induced immune effector mechanisms that would otherwise mediate their destruction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Gang& Levitsky, Hyam. 2012. Towards Curative Cancer Immunotherapy: Overcoming Posttherapy Tumor Escape. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-994333
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Gang& Levitsky, Hyam. Towards Curative Cancer Immunotherapy: Overcoming Posttherapy Tumor Escape. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-994333
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Gang& Levitsky, Hyam. Towards Curative Cancer Immunotherapy: Overcoming Posttherapy Tumor Escape. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-994333
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-994333
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر