Macroprolactinemia: Diagnostic, Clinical, and Pathogenic Significance
المؤلفون المشاركون
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Macroprolactinemia is characterized by a large molecular mass of PRL (macroprolactin) as the main molecular form of PRL in sera, the frequent elevation of serum PRL (hyperprolactinemia), and the lack of symptoms.
Macroprolactin is largely a complex of PRL with immunoglobulin G (IgG), especially anti-PRL autoantibodies.
The prevalence of macroprolactinemia is 10–25% in patients with hyperprolactinemia and 3.7% in general population.
There is no gender difference and a long-term followup demonstrates that macroprolactinemia develops before middle age and is likely a chronic condition.
Polyethylene-glycol- (PEG-) precipitation method is widely used for screening macroprolactinemia, and gel filtration chromatography, protein A/G column, and I125-PRL binding studies are performed to confirm and clarify its nature.
The cross-reactivity of macroprolactin varies widely according to the immunoassay systems.
The epitope on PRL molecule recognized by the autoantibodies is located close to the binding site for PRL receptors, which may explain that macroprolactin has a lower biological activity.
Hyperprolactinemia frequently seen in macroprolactinemic patients is due to the delayed clearance of autoantibody-bound PRL.
When rats are immunized with rat pituitary PRL, anti-PRL autoantibodies are produced and hyperprolactinemia develops, mimicking macroprolactinemia in humans.
Screening of macroprolactinemia is important for the differential diagnosis of hyperprolactinemia to avoid unnecessary examinations and treatments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shimatsu, Akira& Hattori, Naoki. 2012. Macroprolactinemia: Diagnostic, Clinical, and Pathogenic Significance. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994352
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shimatsu, Akira& Hattori, Naoki. Macroprolactinemia: Diagnostic, Clinical, and Pathogenic Significance. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994352
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shimatsu, Akira& Hattori, Naoki. Macroprolactinemia: Diagnostic, Clinical, and Pathogenic Significance. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994352
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-994352
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر