Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells
المؤلفون المشاركون
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Phagocytosis is a major mechanism by which the mediators of innate immunity thwart microbial infections.
Here we demonstrate that human herpesviruses may have evolved a common mechanism to exploit a phagocytosis-like entrapment to gain entry into ocular cells.
While herpes simplex virus-1 (HSV-1) causes corneal keratitis, cytomegalovirus (CMV) is associated with retinitis in immunocompromised individuals.
A third herpesvirus, human herpesvirus-8 (HHV-8), is crucial for the pathogenesis of Kaposi’s sarcoma, a common AIDS-related tumor of eyelid and conjunctiva.
Using laser scanning confocal microscopy, we show that successful infection of ocular cell types by all the three viruses, belonging to three divergent subfamilies of herpesviruses, is facilitated by induction of F-actin rich membrane protrusions.
Inhibitors of F-actin polymerization and membrane protrusion formation, cytochalasin D and latrunculin B, were able to block infection by all three viruses.
Similar inhibition was seen by blocking phosphoinositide 3 kinase signaling, which is required for microbial phagocytosis.
Transmission electron microscopy data using human corneal fibroblasts for HSV-1, human retinal pigment epithelial cells for CMV, and human conjunctival epithelial cells for HHV-8 are consistent with the possibility that pseudopod-like membrane protrusions facilitate virus uptake by the ocular cells.
Our findings suggest a novel mechanism by which the nonprofessional mediators of phagocytosis can be infected by human herpesviruses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tiwari, Vaibhav& Shukla, Deepak. 2012. Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-996778
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tiwari, Vaibhav& Shukla, Deepak. Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-996778
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tiwari, Vaibhav& Shukla, Deepak. Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-996778
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-996778
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر