In Vitro Release of Interferon-Gamma from Peripheral Blood Lymphocytes in Cutaneous Adverse Drug Reactions
المؤلفون المشاركون
Brenner, Sarah
Chodick, Gabriel
Hanson, Meital
Goldberg, Ilan
Shirazi, Idit
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Cutaneous drug reactions are common but diagnostically challenging due to phenotypic heterogeneity and simultaneous exposure to multiple drugs.
These limitations prompted the development of diagnostic tests.
Aims.
To evaluate the performance of an in vitro assay measuring interferon-gamma release from patients’ lymphocytes in the presence of causative drugs for the diagnosis of drug reactions.
Methods.
Mononuclear cells derived from patients were incubated with and without suspected drugs, and increment of interferon-gamma levels was measured by ELISA.
We performed a telephonic survey to evaluate the effect of stopping the drugs incriminated by the assay on cutaneous manifestations.
Results.
We assessed 272 patients who used 1035 medications.
When assessed against the questionnaire data collected at least 6 months after stopping the causative drug, sensitivity was found to be 83.61% and specificity 92.67%.
Likelihood ratio for a positive test is 11.40 and for a negative test 0.18.
Positive predictive value is 75.37% and negative predictive value is 95.47%.
The test was found to perform significantly better in females and in older patients.
Conclusions.
Interferon-gamma release test is a useful adjunct tool in the diagnosis of cutaneous drug reactions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Goldberg, Ilan& Hanson, Meital& Chodick, Gabriel& Shirazi, Idit& Brenner, Sarah. 2012. In Vitro Release of Interferon-Gamma from Peripheral Blood Lymphocytes in Cutaneous Adverse Drug Reactions. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-996787
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Goldberg, Ilan…[et al.]. In Vitro Release of Interferon-Gamma from Peripheral Blood Lymphocytes in Cutaneous Adverse Drug Reactions. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-996787
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Goldberg, Ilan& Hanson, Meital& Chodick, Gabriel& Shirazi, Idit& Brenner, Sarah. In Vitro Release of Interferon-Gamma from Peripheral Blood Lymphocytes in Cutaneous Adverse Drug Reactions. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-996787
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-996787
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر