Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide
المؤلفون المشاركون
Wang, Xiaoxiao
Cai, Duan
Xiang, Jian-Bin
Zhou, Yi-Ming
Yao, Yu-Feng
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Low expression or absence of dendritic cell (DC) surface B7 molecules can induce immune tolerance or hyporesponse.
Whether DCs could induce indirect allogeneic-specific cross-tolerance or hyporesponse to recipient T cells remains unclear.
Methods.
Generated from C3H/He mice bone marrow cells pulsed with donor antigen from C57BL/6 mice, recipient DCs were incubated with B7 antisense peptide (B7AP).
Immune regulatory activities were examined in vitro by a series of mixed lymphocyte reactions.
Murine allogeneic carotid artery orthotopic transplantation was performed from C57BL/6 to C3H/He.
Recipients were given B7AP-treated DCs 7 days before transplantation.
Allograft pathological analysis was done 2 months after transplantation.
Results.
B7AP-pretreated DCs markedly inhibited T-cell proliferation compared with untreated group.
Pretreated T cells exhibited markedly reduced response to alloantigen versus third-party antigen.
Pathological analysis of arterial allografts demonstrated significant reduction of intimal hyperplasia in B7-AP pretreated group versus control.
Conclusion.
Blockade of B7 molecules by B7AP could induce indirect allogeneic-specific hyporesponse and inhibit arterial allograft intimal hyperplasia, which may be involved in future strategies for human allograft chronic rejection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Yu-Feng& Zhou, Yi-Ming& Xiang, Jian-Bin& Wang, Xiaoxiao& Cai, Duan. 2012. Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-996907
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Yu-Feng…[et al.]. Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-996907
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Yu-Feng& Zhou, Yi-Ming& Xiang, Jian-Bin& Wang, Xiaoxiao& Cai, Duan. Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-996907
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-996907
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر