Impact of Previous ART and of ART Initiation on Outcome of HIV-Associated Tuberculosis
المؤلفون المشاركون
Angeletti, Claudio
Matteelli, Alberto
Palmieri, Fabrizio
Vanacore, Paola
Ippolito, Giuseppe
Carbonara, Sergio
Gori, Andrea
Girardi, Enrico
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Combination antiretroviral therapy (cART) has progressively decreased mortality of HIV-associated tuberculosis .To date, however, limited data on tuberculosis treatment outcomes among coinfected patients who are not ART-naive at the time of tuberculosis diagnosis are available.
Methods.
A multicenter, observational study enrolled 246 HIV-infected patients diagnosed with tuberculosis, in 96 Italian infectious diseases hospital units, who started tuberculosis treatment.
A polytomous logistic regression model was used to identify baseline factors associated with the outcome.
A Poisson regression model was used to explain the effect of ART during tuberculosis treatment on mortality, as a time-varying covariate, adjusting for baseline characteristics.
Results.
Outcomes of tuberculosis treatment were as follows: 130 (52.8%) were successfully treated, 36 (14.6%) patients died in a median time of 2 months (range: 0–16), and 80 (32.6%) had an unsuccessful outcome.
Being foreign born or injecting drug users was associated with unsuccessful outcomes.
In multivariable Poisson regression, cART during tuberculosis treatment decreased the risk of death, while this risk increased for those who were not ART-naive at tuberculosis diagnosis.
Conclusions.
ART during tuberculosis treatment is associated with a substantial reduction of death rate among HIV-infected patients.
However, patients who are not ART-naive when they develop tuberculosis remain at elevated risk of death.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Girardi, Enrico& Palmieri, Fabrizio& Angeletti, Claudio& Vanacore, Paola& Matteelli, Alberto& Gori, Andrea…[et al.]. 2012. Impact of Previous ART and of ART Initiation on Outcome of HIV-Associated Tuberculosis. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-996919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Girardi, Enrico…[et al.]. Impact of Previous ART and of ART Initiation on Outcome of HIV-Associated Tuberculosis. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-996919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Girardi, Enrico& Palmieri, Fabrizio& Angeletti, Claudio& Vanacore, Paola& Matteelli, Alberto& Gori, Andrea…[et al.]. Impact of Previous ART and of ART Initiation on Outcome of HIV-Associated Tuberculosis. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-996919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-996919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر