The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target
المؤلفون المشاركون
Morteau, Olivier
Luqmani, Raashid A.
Chakera, Aron
Cornall, Richard J.
Bennett, Sophia C.
Bowness, Paul
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting synovial joints in which the development of autoantibodies represents a failure of normal tolerance mechanisms, suggesting a role for follicular helper T cells (TFH) in the genesis of autoimmunity.
To determine whether quantitative or qualitative abnormalities in the circulating TFH cell population exist, we analysed by flow cytometry the number and profile of these cells in 35 patients with RA and 15 matched controls.
Results were correlated with patient characteristics, including the presence of autoantibodies, disease activity, and treatment with biologic agents.
Circulating TFH cells from patients with RA show significantly increased expression of the immunoglobulin superfamily receptor CD200, with highest levels seen in seropositive patients (P=0.0045) and patients treated with anti-TNFα agents (P=0.0008).
This occurs in the absence of any change in TFH numbers or overt bias towards Th1, Th2, or Th17 phenotypes.
CD200 levels did not correlate with DAS28 scores (P=0.887).
Although the number of circulating TFH cells is not altered in the blood of patients with RA, the TFH cells have a distinct phenotype.
These differences associate TFH cells with the pathogenesis of RA and support the relevance of the CD200/CD200R signalling pathway as a potential therapeutic target.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chakera, Aron& Bennett, Sophia C.& Morteau, Olivier& Bowness, Paul& Luqmani, Raashid A.& Cornall, Richard J.. 2012. The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-996932
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chakera, Aron…[et al.]. The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-996932
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chakera, Aron& Bennett, Sophia C.& Morteau, Olivier& Bowness, Paul& Luqmani, Raashid A.& Cornall, Richard J.. The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-996932
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-996932
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر