Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection
المؤلفون المشاركون
Caliari, Marcelo Vidigal
Wilson, R. Alan
Assis, Natan R. G.
Martins, Vicente P.
Pinheiro, Carina S.
Morais, Suellen B.
Figueiredo, Bárbara C. P.
Castro-Borges, William
Azevedo, Vasco
Oliveira, Sérgio Costa
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The flatworm Schistosoma mansoni is a blood fluke parasite that causes schistosomiasis, a debilitating disease that occurs throughout the developing world.
Current schistosomiasis control strategies are mainly based on chemotherapy, but many researchers believe that the best long-term strategy to control schistosomiasis is through immunization with an antischistosomiasis vaccine combined with drug treatment.
In the search for potential vaccine candidates, numerous tegument antigens have been assessed.
As the major interface between parasite and mammalian host, the tegument plays crucial roles in the establishment and further course of schistosomiasis.
Herein, we evaluated the potential of a GPI fraction, containing representative molecules located on the outer surface of adult worms, as vaccine candidate.
Immunization of mice with GPI-anchored proteins induced a mixed Th1/Th2 type of immune response with production of IFN-γ and TNF-α, and low levels of IL-5 into the supernatant of splenocyte cultures.
The protection engendered by this vaccination protocol was confirmed by 42% reduction in worm burden, 45% reduction in eggs per gram of hepatic tissue, 29% reduction in the number of granulomas per area, and 53% reduction in the granuloma fibrosis.
Taken together, the data herein support the potential of surface-exposed GPI-anchored antigens from the S.
mansoni tegument as vaccine candidate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Martins, Vicente P.& Pinheiro, Carina S.& Figueiredo, Bárbara C. P.& Assis, Natan R. G.& Morais, Suellen B.& Caliari, Marcelo Vidigal…[et al.]. 2012. Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996959
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Martins, Vicente P.…[et al.]. Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-996959
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Martins, Vicente P.& Pinheiro, Carina S.& Figueiredo, Bárbara C. P.& Assis, Natan R. G.& Morais, Suellen B.& Caliari, Marcelo Vidigal…[et al.]. Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996959
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-996959
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر