Possible therapeutic effects of the extremely low-frequency electromagnetic field and broccoli extract in the treatment of PHZ-induced colon cancer in rats

الملخص EN

Colon cancer is the second-most dangerous type of cancer, affecting both men and women worldwide.

Nowadays, scientists aim to increase the effectiveness of existing cancer treatments.

The application of electromagnetic magnetic fields (EMF) in the treatment of different kinds of cancer whether alone or in combination with other treatments seems to be a promising therapy that has drawn attention during the last decades.

Therefore, the current study aimed to investigate the potential beneficial effects of extremely low-frequency electromagnetic field (ELF-EMF) application alone and in combination with broccoli extract in the treatment of colon cancer in an animal model .

25 male Albino rats (Rattus rattus) were randomly divided into five groups:first group was control group, the second group was exposed to ELF-EMF (50 Hz, 0.9 mT) daily for 75 mins for 4 weeks.

the third group was injected intraperitoneally with phenyl hydrazine( PHZ) (90mg/Kg) only twice a week for 4 weeks, the fourth group was injected intraperitoneally with PHZ (90mg/Kg) only twice a week for 4 weeks, then exposed to ELF-EMF daily for 75 mins for another 4 weeks.

And the last group was injected intraperitoneally with PHZ (90mg/Kg) only twice a week for 4 weeks then exposed to ELF-EMF daily for 75 mins and was given broccoli extract orally (300 mg/kg) twice/week regulatory for 4 weeks.

The results revealed that PHZ injection was able to induce carcinogenicity in the intestinal tissues of rats.

While the treatment by ELF-EMF application mitigated the effects of PHZ and succeeded in suppressing tumor progression, especially when combined with broccoli extract.