Biodegradable Polymer-Coated, Gelatin HydrogelBioceramics Ternary Composites for Antitubercular Drug Delivery and Tissue Regeneration
المؤلفون المشاركون
Xue, Mintao
Hu, Hongtao
Jiang, Yuanquan
Liu, Jichun
He, Hailong
Ye, Xiaojian
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
A simple and effective strategy for the treatment of osteoarticular tuberculosis is proposed through combining tissue engineering approach with anti-tuberculosis drug therapy.
A series of tricalcium phosphate bioceramics (TPB) composites, coated by degradable polymer outside and loaded with rifampicin (RFP)-containing gelatin hydrogel inside, were thus fabricated and successfully applied to deliver antitubercular drug RFP into osseous lesion and concomitantly to induce tissue regeneration.
RFP-loaded gelatin hydrogel/TPB composites could be readily prepared by filling RFP-containing gelatin solution into TPB and then in situ crosslinking of gelatin with calcium ions.
Depending on the concentrations of RFP, the loading efficiency of RFP in the composites varied in the range from approximately 2% to 5%.
Moreover, the surface of these binary composites could be further coated by a biodegradable polymer, yielding biodegradable polymer-coated, RFP-containing gelatin hydrogel/TPB ternary composites.
It was shown that in vitro release of RFP from the ternary composites could be effectively sustained for a long period of time.
Besides, these composites revealed good biocompatibility towards the survival of MC-3T3 cells in vitro and could be used for tissue regeneration in vivo in a rabbit model.
The results indicate that TPB ternary composites have great potential for the treatment of osteoarticular tuberculosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xue, Mintao& Hu, Hongtao& Jiang, Yuanquan& Liu, Jichun& He, Hailong& Ye, Xiaojian. 2012. Biodegradable Polymer-Coated, Gelatin HydrogelBioceramics Ternary Composites for Antitubercular Drug Delivery and Tissue Regeneration. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998205
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xue, Mintao…[et al.]. Biodegradable Polymer-Coated, Gelatin HydrogelBioceramics Ternary Composites for Antitubercular Drug Delivery and Tissue Regeneration. Journal of Nanomaterials No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-998205
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xue, Mintao& Hu, Hongtao& Jiang, Yuanquan& Liu, Jichun& He, Hailong& Ye, Xiaojian. Biodegradable Polymer-Coated, Gelatin HydrogelBioceramics Ternary Composites for Antitubercular Drug Delivery and Tissue Regeneration. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998205
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-998205
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر