Immunocytes as a Biocarrier to Delivery Therapeutic and Imaging Contrast Agents to Tumors
المؤلفون المشاركون
Choi, Jinhyang
Woo, Ha-Na
Ju, Eun Jin
Jung, Joohee
Chung, Hye-Kyung
Park, Jaesook
Park, Seok Soon
Shin, Seol Hwa
Park, Hye Ji
Lee, Jin Seong
Song, Si Yeol
Jeong, Seong-Yun
Choi, Eun Kyung
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Radiotherapy for cancer treatment has been used for primary or adjuvant treatment in many types of cancer, and approximately half of all cancer patients are undergoing radiation.
However, ionizing radiation exposure induces genetic alterations in cancer cells and results in recruitment of monocytes/macrophages by triggering signals released from these cells.
Using this characteristic of monocytes/macrophages, we have attempted to develop a biocarrier loading radiosensitizing anticancer agents that can lead to enhance the therapeutic effect of radiation in cancer treatment.
The aim of this study is to demonstrate the proof of this concept.
THP-1 labeled with Qdot 800 or iron oxide (IO) effectively migrated into tumors of subcutaneous mouse model and increased recruitment after ionizing radiation.
Functionalized liposomes carrying a radiosensitizing anticancer agent, doxorubicin, are successfully loaded in THP-1 (THP-1-LP-Dox) with reduced cytotoxicity, and THP-1-LP-Dox also was observed in tumors after intravenous administration.
Here, we report that monocytes/macrophages as a biocarrier can be used as a selective tool for amplification of the therapeutic effects on radiotherapy for human cancer treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Jinhyang& Woo, Ha-Na& Ju, Eun Jin& Jung, Joohee& Chung, Hye-Kyung& Park, Jaesook…[et al.]. 2012. Immunocytes as a Biocarrier to Delivery Therapeutic and Imaging Contrast Agents to Tumors. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998574
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Jinhyang…[et al.]. Immunocytes as a Biocarrier to Delivery Therapeutic and Imaging Contrast Agents to Tumors. Journal of Nanomaterials No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-998574
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Jinhyang& Woo, Ha-Na& Ju, Eun Jin& Jung, Joohee& Chung, Hye-Kyung& Park, Jaesook…[et al.]. Immunocytes as a Biocarrier to Delivery Therapeutic and Imaging Contrast Agents to Tumors. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998574
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-998574
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر