Preparation and Characterization of Folate Targeting Magnetic Nanomedicine Loaded with Cisplatin
المؤلفون المشاركون
Xie, Minqiang
Xu, Yiming
Liu, Jie
Zhang, Tao
Zhang, Hongzheng
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We used Aldehyde sodium alginate (ASA) as modifier to improve surfactivity and stability of magnetic nanoparticles, and folate acid (FA) as targeting molecule.
Fe3O4 nanoparticles were prepared by chemical coprecipitation method.
FA was activated and coupled with diaminopolyethylene glycol (NH2-PEG-NH2).
ASA was combined with Fe3O4 nanoparticles, and FA-PEG was connected with ASA by Schiff’s base formation.
Then Cl- in cisplatin was replaced by hydroxyl group in ASA, and FA- and ASA-modified cisplatin-loaded magnetic nanomedicine (CDDP-FA-ASA-MNPs) was prepared.
This nanomedicine was characterized by transmission electron microscopy, dynamic lighterring scattering, phase analysis light scattering and vibrating sample magnetometer.
The uptake of magnetic nanomedicine by nasopharyngeal and laryngeal carcinoma cells with folate receptor positive or negative expression were observed by Prussian blue iron stain and transmission electron microscopy.
We found that CDDP-FA-ASA-MNPs have good water-solubility and stability.
Mean diameter of Fe3O4 core was 8.17 ± 0.24 nm, hydrodynamic diameters was 110.90±1.70 nm, and zeta potential was -26.45±1.26 mV.
Maximum saturation magnetization was 22.20 emu/g.
CDDP encapsulation efficiency was 49.05±1.58% (mg/mg), and drug loading property was 14.31±0.49% (mg/mg).
In vitro, CDDP-FA-ASA-MNPs were selectively taken up by HNE-1 cells and Hep-2 cells, which express folate receptor positively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Minqiang& Xu, Yiming& Liu, Jie& Zhang, Tao& Zhang, Hongzheng. 2012. Preparation and Characterization of Folate Targeting Magnetic Nanomedicine Loaded with Cisplatin. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-998641
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Minqiang…[et al.]. Preparation and Characterization of Folate Targeting Magnetic Nanomedicine Loaded with Cisplatin. Journal of Nanomaterials No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-998641
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Minqiang& Xu, Yiming& Liu, Jie& Zhang, Tao& Zhang, Hongzheng. Preparation and Characterization of Folate Targeting Magnetic Nanomedicine Loaded with Cisplatin. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-998641
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-998641
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر