Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma
المؤلفون المشاركون
Meng, Wei
Paunel-Görgülü, Adnana
Flohé, Sascha
Witte, Ingo
Schädel-Höpfner, Michael
Windolf, Joachim
Lögters, Tim Tobias
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Neutrophil extracellular traps (NET) consist of a DNA scaffold that can be destroyed by Deoxyribonuclease (DNase).
Thus DNases are potential prerequisites for natural counter regulation of NETs formation.
In the present study, we determined the relationship of NETs and DNase after major trauma.
Methods.
Thirty-nine major trauma patients, 14 with and 25 without sepsis development were enrolled in this prospective study.
Levels of cell-free (cf)-DNA/NETs and DNase were quantified daily from admission until day 9 after admission.
Results.
Levels of cf-DNA/NETs in patients who developed sepsis were significantly increased after trauma.
In the early septic phase, DNase values in septic patients were significantly increased compared to patients without sepsis (P<0.05).
cf-DNA/NETs values correlated to values of DNase in all trauma patients and patients with uneventful recovery (P<0.01) but not in septic patients.
Recombinant DNase efficiently degraded NETs released by stimulated neutrophils in a concentration-dependent manner in vitro.
Conclusions.
DNase degrades NETs in a concentration-dependent manner and therefore could have a potential regulatory effect on NET formation in neutrophils.
This may inhibit the antibacterial effects of NETs or protect the tissue from autodestruction in inadequate NETs release in septic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Wei& Paunel-Görgülü, Adnana& Flohé, Sascha& Witte, Ingo& Schädel-Höpfner, Michael& Windolf, Joachim…[et al.]. 2012. Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998833
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Wei…[et al.]. Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-998833
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Wei& Paunel-Görgülü, Adnana& Flohé, Sascha& Witte, Ingo& Schädel-Höpfner, Michael& Windolf, Joachim…[et al.]. Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998833
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-998833
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر