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Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges
المؤلفون المشاركون
Víteček, Jan
Lojek, Antonín
Kubala, Lukas
Giuseppe, Valacchi
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-04
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
In the past three decades, nitric oxide has been well established as an important bioactive molecule implicated in regulation of cardiovascular, nervous, and immune systems.
Therefore, it is not surprising that much effort has been made to find specific inhibitors of nitric oxide synthases (NOS), the enzymes responsible for production of nitric oxide.
Among the many NOS inhibitors developed to date, inhibitors based on derivatives and analogues of arginine are of special interest, as this category includes a relatively high number of compounds with good potential for experimental as well as clinical application.
Though this group of inhibitors covers early nonspecific compounds, modern drug design strategies such as biochemical screening and computer-aided drug design have provided NOS-isoform-specific inhibitors.
With an emphasis on major advances in this field, a comprehensive list of inhibitors based on their structural characteristics is discussed in this paper.
We provide a summary of their biochemical properties as well as their observed effects both in vitro and in vivo.
Furthermore, we focus in particular on their pharmacology and use in recent clinical studies.
The potential of newly designed specific NOS inhibitors developed by means of modern drug development strategies is highlighted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Víteček, Jan& Lojek, Antonín& Giuseppe, Valacchi& Kubala, Lukas. 2012. Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-22.
https://search.emarefa.net/detail/BIM-998873
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Víteček, Jan…[et al.]. Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges. Mediators of Inflammation No. 2012 (2012), pp.1-22.
https://search.emarefa.net/detail/BIM-998873
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Víteček, Jan& Lojek, Antonín& Giuseppe, Valacchi& Kubala, Lukas. Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-22.
https://search.emarefa.net/detail/BIM-998873
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-998873
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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