Muscarinic Receptors and Their Antagonists in COPD: Anti-Inflammatory and Antiremodeling Effects

المؤلفون المشاركون

Karakiulakis, George
Roth, Michael

المصدر

Mediators of Inflammation

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-11-24

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض

الملخص EN

Muscarinic receptors are expressed by most cell types and mediate cellular signaling of their natural ligand acetylcholine.

Thereby, they control numerous central and peripheral physiological organ responses to neuronal activity.

In the human lung, muscarinic receptors are predominantly expressed by smooth muscle cells, epithelial cells, and fibroblasts.

Antimuscarinic agents are used for the treatment of chronic obstructive pulmonary disease and to a lesser extent for asthma.

They are primarily used as bronchodilators, but it is now accepted that they are also associated with anti-inflammatory, antiproliferative, and antiremodeling effects.

Remodeling of the small airways is a major pathology in COPD and impairs lung function through changes of the extracellular matrix.

Glycosaminoglycans, particularly hyaluronic acid, and matrix metalloproteases are among extracellular matrix molecules that have been associated with tissue inflammation and remodeling in lung diseases, including chronic obstructive pulmonary disease and asthma.

Since muscarinic receptors have been shown to influence the homeostasis of glycosaminoglycans and matrix metalloproteases, these molecules may be proved valuable endpoint targets in clinical studies for the pharmacological exploitation of the anti-inflammatory and antiremodeling effects of muscarinic inhibitors in the treatment of chronic obstructive pulmonary disease and asthma.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Karakiulakis, George& Roth, Michael. 2012. Muscarinic Receptors and Their Antagonists in COPD: Anti-Inflammatory and Antiremodeling Effects. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-998897

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Karakiulakis, George& Roth, Michael. Muscarinic Receptors and Their Antagonists in COPD: Anti-Inflammatory and Antiremodeling Effects. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-998897

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Karakiulakis, George& Roth, Michael. Muscarinic Receptors and Their Antagonists in COPD: Anti-Inflammatory and Antiremodeling Effects. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-998897

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-998897