Erythromycin Enhances CD4+Foxp3+ Regulatory T-Cell Responses in a Rat Model of Smoke-Induced Lung Inflammation

المؤلفون المشاركون

Bai, Jing
Qiu, Shi-Lin
Zhong, Xiao-Ning
Huang, Qiu-Ping
He, Zhi-Yi
Zhang, Jian-Quan
Liu, Guang-Nan
Li, Mei-Hua
Deng, Jing-Min

المصدر

Mediators of Inflammation

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-04-12

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض

الملخص EN

Heavy smoking can induce airway inflammation and emphysema.

Macrolides can modulate inflammation and effector T-cell response in the lungs.

However, there is no information on whether erythromycin can modulate regulatory T-cell (Treg) response.

This study is aimed at examining the impact of erythromycin on Treg response in the lungs in a rat model of smoking-induced emphysema.

Male Wistar rats were exposed to normal air or cigarette smoking daily for 12 weeks and treated by gavage with 100 mg/kg of erythromycin or saline daily beginning at the forth week for nine weeks.

The lung inflammation and the numbers of inflammatory infiltrates in bronchoalveolar lavage fluid (BALF) were characterized.

The frequency, the number of Tregs, and the levels of Foxp3 expression in the lungs and IL-8, IL-35, and TNF-α in BALF were determined by flow cytometry, RT-PCR and ELISA, respectively.

Treatment with erythromycin reduced smoking-induced inflammatory infiltrates, the levels of IL-8 and TNF-α in the BALF and lung damages but increased the numbers of CD4+Foxp3+ Tregs and the levels of Foxp3 transcription in the lungs, accompanied by increased levels of IL-35 in the BALF of rats.

Our novel data indicated that erythromycin enhanced Treg responses, associated with the inhibition of smoking-induced inflammation in the lungs of rats.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Bai, Jing& Qiu, Shi-Lin& Zhong, Xiao-Ning& Huang, Qiu-Ping& He, Zhi-Yi& Zhang, Jian-Quan…[et al.]. 2012. Erythromycin Enhances CD4+Foxp3+ Regulatory T-Cell Responses in a Rat Model of Smoke-Induced Lung Inflammation. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-998902

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Bai, Jing…[et al.]. Erythromycin Enhances CD4+Foxp3+ Regulatory T-Cell Responses in a Rat Model of Smoke-Induced Lung Inflammation. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-998902

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Bai, Jing& Qiu, Shi-Lin& Zhong, Xiao-Ning& Huang, Qiu-Ping& He, Zhi-Yi& Zhang, Jian-Quan…[et al.]. Erythromycin Enhances CD4+Foxp3+ Regulatory T-Cell Responses in a Rat Model of Smoke-Induced Lung Inflammation. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-998902

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-998902