Pathological study and genetic diagnosis of vinblastine effects on dna of ovary and testes in mouse
Other Title(s)
دراسة جزيئية-نسيجية-مرضية في تأثيرالفنبلاستين في دنا المبيض و الخصى في الفئران البيضاء
Joint Authors
Hammadi, Taghrid Jabbar
al-Amiri, Muna Sajit Hashim
Mahmud, Dhikra Abd Allah
Muhammad, Suad Abd al-Karim
Nasir, Rabab Abd al-Amir
Source
Publisher
University of Diyala College of Agriculture
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
English Abstract
The present study was designed in order to identify the effects of vinblastine on ovary and testes and then on fertilization capacity and pregnancy outcome in white mice, fifty mixed mice were used, 10 treated male were mated with 10 untreated female, 10 untreated male were mated with 10 treated female, and (10) mixed mice as control.
Results of male test showed decline in sperm count with spermatocytes' morphological deformity.
The results of molecular technique applied on testicular section and ovarian section, showed that green signals, indicating the damage on TK (11qE2)/XY gene on chromosome of sperm and ova, red signal indicate intact gene yellowish signals indicated translocation on the same gene (mutation).
Pathological findings showed marked loss of spermatogenesis (Azoospermia) with damage in testes' tissues; fibrosis of ovarian stroma with degenerative changes on ovary and evidence of early embryonic death with ence or low fertility
Data Type
Conference Papers
Record ID
BIM-1136492
American Psychological Association (APA)
al-Amiri, Muna Sajit Hashim& Muhammad, Suad Abd al-Karim& Nasir, Rabab Abd al-Amir& Mahmud, Dhikra Abd Allah& Hammadi, Taghrid Jabbar. 2018-12-31. Pathological study and genetic diagnosis of vinblastine effects on dna of ovary and testes in mouse. . Vol. 10, Special issue (2018), pp.35-46.ديالى، العراق : جامعة ديالى، كلية الزراعة،.
https://search.emarefa.net/detail/BIM-1136492
Modern Language Association (MLA)
al-Amiri, Muna Sajit Hashim…[et al.]. Pathological study and genetic diagnosis of vinblastine effects on dna of ovary and testes in mouse. . ديالى، العراق : جامعة ديالى، كلية الزراعة،. 2018-12-31.
https://search.emarefa.net/detail/BIM-1136492
American Medical Association (AMA)
al-Amiri, Muna Sajit Hashim& Muhammad, Suad Abd al-Karim& Nasir, Rabab Abd al-Amir& Mahmud, Dhikra Abd Allah& Hammadi, Taghrid Jabbar. Pathological study and genetic diagnosis of vinblastine effects on dna of ovary and testes in mouse. .
https://search.emarefa.net/detail/BIM-1136492