KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature

الملخص EN

Ovarian-like epithelial tumors of the testis, including serous borderline tumors, are rare entities.

We report the case of a 60-year-old man with a left intratesticular mass who had a radical orchidectomy.

Histologically, the tumor was identical to the ovarian counterpart showing a well-delineated cystic lesion characterized by intraluminal papillae.

The papillae are lined by atypical cuboidal or ciliated cells and are associated with psammoma bodies.

The tumor cells express cytokeratin 7 (CK7), cytokeratin 5-6 (CK5-6), cancer antigen 125 (CA125), estrogen (ER), progesterone (PR), Wilm’s tumor gene (WT1), paired box gene 8 (PAX8), Ber-EP4, and epithelial membrane antigen (EMA).

The diagnosis of a serous borderline tumor of the testis was proposed.

Mutation testing using next-generation sequencing showed a Q61K KRAS gene mutation.

To the best of our knowledge, this is the second case report of a serous borderline tumor of the testis with a Q61K KRAS gene mutation.