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KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature
Joint Authors
Buri, Sarah
Noël, Jean-Christophe
Catteau, Xavier
D’Haene, Nicky
Al Hajj Obeid, Walid
Svistakov, Ilyas
Rorive, Sandrine
Roumeguère, Thierry
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Ovarian-like epithelial tumors of the testis, including serous borderline tumors, are rare entities.
We report the case of a 60-year-old man with a left intratesticular mass who had a radical orchidectomy.
Histologically, the tumor was identical to the ovarian counterpart showing a well-delineated cystic lesion characterized by intraluminal papillae.
The papillae are lined by atypical cuboidal or ciliated cells and are associated with psammoma bodies.
The tumor cells express cytokeratin 7 (CK7), cytokeratin 5-6 (CK5-6), cancer antigen 125 (CA125), estrogen (ER), progesterone (PR), Wilm’s tumor gene (WT1), paired box gene 8 (PAX8), Ber-EP4, and epithelial membrane antigen (EMA).
The diagnosis of a serous borderline tumor of the testis was proposed.
Mutation testing using next-generation sequencing showed a Q61K KRAS gene mutation.
To the best of our knowledge, this is the second case report of a serous borderline tumor of the testis with a Q61K KRAS gene mutation.
American Psychological Association (APA)
Buri, Sarah& Noël, Jean-Christophe& Catteau, Xavier& Al Hajj Obeid, Walid& Svistakov, Ilyas& Roumeguère, Thierry…[et al.]. 2020. KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature. Case Reports in Urology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1151788
Modern Language Association (MLA)
Buri, Sarah…[et al.]. KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature. Case Reports in Urology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1151788
American Medical Association (AMA)
Buri, Sarah& Noël, Jean-Christophe& Catteau, Xavier& Al Hajj Obeid, Walid& Svistakov, Ilyas& Roumeguère, Thierry…[et al.]. KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature. Case Reports in Urology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1151788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151788