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HLA class I and class II polymorphisms and anti-nuclear antibodies in hyperprolactinaemic Iraqi females with primary infertility
Joint Authors
al-Tamimi, Manal Badi Salih
al-Rikabi, Nahi Yusuf Yasin
al-Samirrai, Sabah Mahmud Husayn
Adhiah, Ali Husayn
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 50, Issue 4 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2008-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : the study was conducted to investigate the association between hyperprolactinaemia and markers of human leukocyte antigen (HLA) system in a sample of Iraqi infertile females, together with the profile anti-nuclear antibodies (ANA).
Objectives : one hundred and seventy five female patients (age range : 20 -40 years) were recruited in this study.
They were attending the Institute for Embryo Research and Infertility.
Treatment (Al-Nahrain University) during the period January 2005 - September 2006.
Results : after clinical and laboratry evaluations, it was found that 100 patients were hyperprolactinaemic, whereas the other 75 patients were euprolactinaemic, therefore, they were considered as a control group.
Based on serum level of prolactin (22-29, 30-39 and ≥ 40 Ng / ml), the total hyperprolactinaemic patients were divided into three groups; I (35 patients), II (40 patients) and III (25 patients), respectively.
The HLA antigens showed significant variations between patients (total and groups) and controls.
In total patients, B8 (25.0 vs 9.3 %), DR3 (48.0 vs.
17.3 %) and DR4 (39.0 vs.
13.3 %) showed significant increased frequencies, while B35 showed a significant decreased frequency (7.0 vs.
24 %).
The latter decrease was also observed (5.7 vs.
24.0 %) in group I of patients, which also showed a significant increased frequency of DR3 (54.3 vs.
17.3 %).
In groups II and III of patients, only DR3 (45.0 and 56.0, respectively vs.
17.3 %) and DR4 (37.5 and 56.0, respectively vs.
13.3 %) showed significant increased frequencies.
Autoantibody evaluation by ANA test revealed that 22 % of the total patients was positive, while all control subjects were negative, and such positivity paralleled the increased level of serum prolactin.
American Psychological Association (APA)
Adhiah, Ali Husayn& al-Tamimi, Manal Badi Salih& al-Samirrai, Sabah Mahmud Husayn& al-Rikabi, Nahi Yusuf Yasin. 2008. HLA class I and class II polymorphisms and anti-nuclear antibodies in hyperprolactinaemic Iraqi females with primary infertility. Journal of the Faculty of Medicine Baghdad،Vol. 50, no. 4, pp.1-5.
https://search.emarefa.net/detail/BIM-331584
Modern Language Association (MLA)
Adhiah, Ali Husayn…[et al.]. HLA class I and class II polymorphisms and anti-nuclear antibodies in hyperprolactinaemic Iraqi females with primary infertility. Journal of the Faculty of Medicine Baghdad Vol. 50, no. 4 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-331584
American Medical Association (AMA)
Adhiah, Ali Husayn& al-Tamimi, Manal Badi Salih& al-Samirrai, Sabah Mahmud Husayn& al-Rikabi, Nahi Yusuf Yasin. HLA class I and class II polymorphisms and anti-nuclear antibodies in hyperprolactinaemic Iraqi females with primary infertility. Journal of the Faculty of Medicine Baghdad. 2008. Vol. 50, no. 4, pp.1-5.
https://search.emarefa.net/detail/BIM-331584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-331584