Synthesis and antimicrobial screening of tetra schiff bases of 1, 2, 4, 5-tetra (5-amino- 1, 3, 4-thiadiazole-2-yl)benzene
Joint Authors
Salih, Nadiyah Abd al-Karim
Yusuf, Imad
Salimon, Jumat
Rentschler, Eva
Hamid, Ayyad
Katan, Mustafa
Source
Journal of Saudi Chemical Society
Issue
Vol. 18, Issue 3 (31 Jul. 2014), pp.269-275, 7 p.
Publisher
Publication Date
2014-07-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
In the present study, novel tetra Schiff bases were synthesized by condensation of 1,2,4,5- tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene with different aromatic aldehydes.
The chemical structures were confirmed by means of IR, 1H NMR, 13C NMR, and elemental analysis.
All compounds were screened for antibacterial (Staphylococcus aureus ATCC-9144, Staphylococcus epidermidis ATCC-155, Micrococcus luteus ATCC-4698, Bacillus cereus ATCC-11778, Escherichia coli ATCC- 25922, and Pseudomonas aeruginosa ATCC-2853) and antifungal (Aspergillus niger ATCC-9029 and Aspergillus fumigatus ATCC-46645) activities by paper disc diffusion technique.
The minimum inhibitory concentrations (MICs) of the compounds were also determined by agar streak dilution method.
Among the synthesized compounds 1,2,4,5-tetra[5-(4-nitrobenzylideneamino)-1,3,4-thiadiazole- 2-yl]benzene 7 was found to be the most potent antimicrobial activity with MICs of 3.4, 2.1, 1.2, 2.0, 3.1, 2.4, 1.1, and 1.7 lg/mL against the above mentioned respective strains.-
American Psychological Association (APA)
Yusuf, Imad& Rentschler, Eva& Salih, Nadiyah Abd al-Karim& Salimon, Jumat& Hamid, Ayyad& Katan, Mustafa. 2014. Synthesis and antimicrobial screening of tetra schiff bases of 1, 2, 4, 5-tetra (5-amino- 1, 3, 4-thiadiazole-2-yl)benzene. Journal of Saudi Chemical Society،Vol. 18, no. 3, pp.269-275.
https://search.emarefa.net/detail/BIM-387088
Modern Language Association (MLA)
Yusuf, Imad…[et al.]. Synthesis and antimicrobial screening of tetra schiff bases of 1, 2, 4, 5-tetra (5-amino- 1, 3, 4-thiadiazole-2-yl)benzene. Journal of Saudi Chemical Society Vol. 18, no. 3 (Jul. 2014), pp.269-275.
https://search.emarefa.net/detail/BIM-387088
American Medical Association (AMA)
Yusuf, Imad& Rentschler, Eva& Salih, Nadiyah Abd al-Karim& Salimon, Jumat& Hamid, Ayyad& Katan, Mustafa. Synthesis and antimicrobial screening of tetra schiff bases of 1, 2, 4, 5-tetra (5-amino- 1, 3, 4-thiadiazole-2-yl)benzene. Journal of Saudi Chemical Society. 2014. Vol. 18, no. 3, pp.269-275.
https://search.emarefa.net/detail/BIM-387088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p.275
Record ID
BIM-387088