Synthesis and antimicrobial screening of tetra schiff bases of 1, 2, 4, 5-tetra (5-amino- 1, 3, 4-thiadiazole-2-yl)‎benzene

Abstract EN

In the present study, novel tetra Schiff bases were synthesized by condensation of 1,2,4,5- tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene with different aromatic aldehydes.

The chemical structures were confirmed by means of IR, 1H NMR, 13C NMR, and elemental analysis.

All compounds were screened for antibacterial (Staphylococcus aureus ATCC-9144, Staphylococcus epidermidis ATCC-155, Micrococcus luteus ATCC-4698, Bacillus cereus ATCC-11778, Escherichia coli ATCC- 25922, and Pseudomonas aeruginosa ATCC-2853) and antifungal (Aspergillus niger ATCC-9029 and Aspergillus fumigatus ATCC-46645) activities by paper disc diffusion technique.

The minimum inhibitory concentrations (MICs) of the compounds were also determined by agar streak dilution method.

Among the synthesized compounds 1,2,4,5-tetra[5-(4-nitrobenzylideneamino)-1,3,4-thiadiazole- 2-yl]benzene 7 was found to be the most potent antimicrobial activity with MICs of 3.4, 2.1, 1.2, 2.0, 3.1, 2.4, 1.1, and 1.7 lg/mL against the above mentioned respective strains.-