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Solvent-free one-pot multicomponent, synthesis, characterization and anti-bacterial activity, of some 2-substituted-3-cyano-pyridine derivatives
Other Title(s)
تخليق (بدون مذيب بوعاء واحد متعدد المكونات) لبعض مشتقات 2-معوض-3-سيانو بريدين و دراسة خواصھا البايولوجية و فعاليتھا
Joint Authors
Ibrahim, Ahmad Khamis
al-Rawi, Muna Samir Said
Ayyub, Zakariyya Hadi
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 28, Issue 2 (31 Aug. 2015), pp.126-135, 10 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2015-08-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Topics
Abstract EN
Solvent- free thermal heating, one-pot condensation of acetophenone, ethyl cyanoacetate or malononitrle and substituted Aromatic aldehyde, ammonium acetate give, 2-oxo-3-cyano-4-substituted Aryl-6-phenyl pyridine [I]a-h , or 2-amino-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives[II]a-f , respectively.
Treatment of compounds 2-oxo-3-cyano-4-substituted Aryl-6-phenyl pyridine with phosphorous penta sulphide (P2S5), give 2-thioxo-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives[III]a-c.
All prepared compounds are characterized by, C.H.N.S-elmental analysis, melting points, FTIR-and1H-NMR-spectral analysis.
Antibacterial examination of synthesized compounds [I]a-c , [II]a-c and [III]a-c against five types of, (G-) and (G+) bacterial.
in comparison with common antibiotic like Ampicillin, Amoxicilin and Lincomycin the result shows 2-thioxo-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives are more reactive than 2-oxo-3-cyano pyridine derivatives or 2-amino-3-cyano pyridine derivatives.
American Psychological Association (APA)
Ayyub, Zakariyya Hadi& al-Rawi, Muna Samir Said& Ibrahim, Ahmad Khamis. 2015. Solvent-free one-pot multicomponent, synthesis, characterization and anti-bacterial activity, of some 2-substituted-3-cyano-pyridine derivatives. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 28, no. 2, pp.126-135.
https://search.emarefa.net/detail/BIM-618614
Modern Language Association (MLA)
Ayyub, Zakariyya Hadi…[et al.]. Solvent-free one-pot multicomponent, synthesis, characterization and anti-bacterial activity, of some 2-substituted-3-cyano-pyridine derivatives. Ibn al-Haitham Journal for Pure and Applied Science Vol. 28, no. 2 (2015), pp.126-135.
https://search.emarefa.net/detail/BIM-618614
American Medical Association (AMA)
Ayyub, Zakariyya Hadi& al-Rawi, Muna Samir Said& Ibrahim, Ahmad Khamis. Solvent-free one-pot multicomponent, synthesis, characterization and anti-bacterial activity, of some 2-substituted-3-cyano-pyridine derivatives. Ibn al-Haitham Journal for Pure and Applied Science. 2015. Vol. 28, no. 2, pp.126-135.
https://search.emarefa.net/detail/BIM-618614
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 132-134
Record ID
BIM-618614