Solvent-free one-pot multicomponent, synthesis, characterization and anti-bacterial activity, of some 2-substituted-3-cyano-pyridine derivatives

Abstract EN

Solvent- free thermal heating, one-pot condensation of acetophenone, ethyl cyanoacetate or malononitrle and substituted Aromatic aldehyde, ammonium acetate give, 2-oxo-3-cyano-4-substituted Aryl-6-phenyl pyridine [I]a-h , or 2-amino-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives[II]a-f , respectively.

Treatment of compounds 2-oxo-3-cyano-4-substituted Aryl-6-phenyl pyridine with phosphorous penta sulphide (P2S5), give 2-thioxo-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives[III]a-c.

All prepared compounds are characterized by, C.H.N.S-elmental analysis, melting points, FTIR-and1H-NMR-spectral analysis.

Antibacterial examination of synthesized compounds [I]a-c , [II]a-c and [III]a-c against five types of, (G-) and (G+) bacterial.

in comparison with common antibiotic like Ampicillin, Amoxicilin and Lincomycin the result shows 2-thioxo-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives are more reactive than 2-oxo-3-cyano pyridine derivatives or 2-amino-3-cyano pyridine derivatives.