Protective effect of ginger (Zingiber Officinal)‎ hydro alcoholic extract on cadmium chloride induced reproductive toxicity in rats female

Abstract EN

The present study was conducted to explore the protective effects of ginger on cadmium chloride induced reproductive toxicity in rats female .40 female adult rats 6-8 weeks old weighing (260 -300 gm.) was used for the study.

Animals was divided into four (10 rats for each groups) groups: Animals in Groups I:served as control and were given distilled water.

Group II :was given cadmium chloride at a dose of 0.008 mg/kg B.w once daily for two months by oral gavage tube .Group :III were given cadmium chloride at a dose of 0.008 mg/kg B.w once daily along with ginger extract 200 mg/kg B.w.

through oral gavage tube once daily for two months .Group IV: were given ginger extract 200 mg/kg B.w.

through oral gavage tube once daily for two months .At the end of the experiment, blood samples were taken via cardiac puncture for follicular stimulating hormone (FSH), luteinizing hormone (LH) analysis .After dissection of animals ,uterui and ovaries were excised for histopathological examination .Results showed that cadmium chloride cause a significant decrease in the levels of sex hormones , and induce toxicopathological changes in genital organs these changes were ameliorated with extract of ginger.

The results of the present study concluded that cadmium chloride -induce toxicopathological changes in uterui and ovaries of rats, which in turn many affected on the reproductive efficiency of animals, these changes were improved after co -giving ginger extract which provide a strong evidence for the beneficial role of antioxidants plants in improving the effect of cadmium chloride toxicity in rats female.