The sedative, analgesic and cardiovascular effects of high dose of xylazine with or without atropine in water buffalo calves (Bubalus Bubalis)
Joint Authors
Shukri, Mustafa
Kamal, Tarik
Atiba, Ayman
Jumah, Najla
Ghazi, Ala Abd al-Munim
Source
Kafr El-Sheikh Veterinary Medical Journal
Issue
Vol. 13, Issue 1 (30 Jun. 2015), pp.155-172, 18 p.
Publisher
Kafr El-Sheikh University Faculty of Veterinary Medicine
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The objective of this study is to evaluate and compare the sedative, analgesic and cardiovascular effects of high dose of xylazine alone and with atropine in buffalo calves.
In an experimental crossover study, calves were treated with xylazine 0.1mg/kg (X1), xylazine 0.15 mg/kg (X2), atropine-xylazine 0.04 mg/kg and 0.1 mg/kg (AX1) and atropine-xylazine 0.04 mg/kg and 0.15 mg/kg (AX2).
The onset and duration of sedation and analgesia effects, ECG, physiological and haemato-biochemical parameters were evaluated.
All treatments resulted in deep sedation and mild to moderate analgesia started after 5 min from the injection.
The duration of sedation achieved with X1, X2, AX1 and AX2 was 89±8, 105±6, 73±5 and 87±7 min respectively.
While, the duration of analgesia achieved with X1, X2, AX1 and AX2 was 75±2, 86±5, 60±3 and 76±5 min respectively.
Heart rate was significantly decreased after X1 and X2 (p<0.01) while it was significantly increased after AX1 and AX2 administration (p< 0.05).
In ECG, 2nd degree heart block developed after X1 and X2 administration.
Salivation was decreased after AX1 and AX2.
All haemato-biochemical parameters return to baseline levels at 24h.
In conclusion, both xylazine and atropine-xylazine produce similar sedative and analgesic effects, but, atropine effectively antagonist the high dose of xylazine associated bradycardia and increased salivation.
Therefore, we suggested that it may be safely to use atropine-xylazine combination in buffalo calves
American Psychological Association (APA)
Atiba, Ayman& Ghazi, Ala Abd al-Munim& Jumah, Najla& Kamal, Tarik& Shukri, Mustafa. 2015. The sedative, analgesic and cardiovascular effects of high dose of xylazine with or without atropine in water buffalo calves (Bubalus Bubalis). Kafr El-Sheikh Veterinary Medical Journal،Vol. 13, no. 1, pp.155-172.
https://search.emarefa.net/detail/BIM-774175
Modern Language Association (MLA)
Atiba, Ayman…[et al.]. The sedative, analgesic and cardiovascular effects of high dose of xylazine with or without atropine in water buffalo calves (Bubalus Bubalis). Kafr El-Sheikh Veterinary Medical Journal Vol. 13, no. 1 (2015), pp.155-172.
https://search.emarefa.net/detail/BIM-774175
American Medical Association (AMA)
Atiba, Ayman& Ghazi, Ala Abd al-Munim& Jumah, Najla& Kamal, Tarik& Shukri, Mustafa. The sedative, analgesic and cardiovascular effects of high dose of xylazine with or without atropine in water buffalo calves (Bubalus Bubalis). Kafr El-Sheikh Veterinary Medical Journal. 2015. Vol. 13, no. 1, pp.155-172.
https://search.emarefa.net/detail/BIM-774175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 169-172
Record ID
BIM-774175