Promising roles of erythropoietin and lymphotoxin alpha in critical illness : a pilot study in critically ill children
المؤلفون المشاركون
Marzuq, Huda
al-Shirbini, Siham A.
Kamal, Sali
Ali, Alya Abbas
Rashid, Layla
المصدر
Egyptian Pediatric Association Gazette
العدد
المجلد 66، العدد 1 (31 مارس/آذار 2018)، ص ص. 28-34، 7ص.
الناشر
تاريخ النشر
2018-03-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Several studies proved the anti-inflammatory role of erythropoietin.
Little is known about the anti-inflammatory role of lymphotoxin alpha (LT-a).
This study was designed to investigate the patterns of erythropoietin (EPO) and LT-a levels in children with acute critical illness.
Patients and methods : Thirty-two critically ill children were prospectively subjected to serial estimation of EPO and LT-a levels, during the first 10 days of admission to one of the pediatric intensive care unit of Cairo University.
Thirteen healthy children served as control.
Results : Serial EPO and LT-a measurements showed significant increases over time early in their critical illness (P < 0.001, respectively).
Both cytokines showed significant increases in survivors (P < 0.001, respectively).
Kaplan Meier survival analysis revealed a significant increase in mortality with LT-a levels below 108.7 pg/ml, (P < 0.01) on admission.
However, EPO did not show any significant difference between survivors and non-survivors.
For both LT-a and EPO, levels at day 1 showed a significant decrease in septic patients.
EPO levels were significantly elevated on day 1 of admission in non-anemic [mean hemoglobin level (11.8 ± 0.9) g/dL, mean EPO level (110.85 ± 44.5) mIU/ml] compared with anemic patients [mean hemoglobin level (9.3 ± 1.3) g/dL, mean EPO level (69.84 ± 30.763) mIU/ml], 95% CI [13.896–68.112], P < (0.01).
Conclusions : Both EPO and LT-a showed significant increment in critically ill children especially in survivors.
Our data strongly suggest that, LT-a may have an anti-inflammatory role in children with acute critical illness.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Shirbini, Siham A.& Ali, Alya Abbas& Kamal, Sali& Marzuq, Huda& Rashid, Layla. 2018. Promising roles of erythropoietin and lymphotoxin alpha in critical illness : a pilot study in critically ill children. Egyptian Pediatric Association Gazette،Vol. 66, no. 1, pp.28-34.
https://search.emarefa.net/detail/BIM-783241
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Shirbini, Siham A.…[et al.]. Promising roles of erythropoietin and lymphotoxin alpha in critical illness : a pilot study in critically ill children. Egyptian Pediatric Association Gazette Vol. 66, no. 1 (Mar. 2018), pp.28-34.
https://search.emarefa.net/detail/BIM-783241
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Shirbini, Siham A.& Ali, Alya Abbas& Kamal, Sali& Marzuq, Huda& Rashid, Layla. Promising roles of erythropoietin and lymphotoxin alpha in critical illness : a pilot study in critically ill children. Egyptian Pediatric Association Gazette. 2018. Vol. 66, no. 1, pp.28-34.
https://search.emarefa.net/detail/BIM-783241
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 33-34
رقم السجل
BIM-783241
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر