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Promising roles of erythropoietin and lymphotoxin alpha in critical illness : a pilot study in critically ill children
Joint Authors
Marzuq, Huda
al-Shirbini, Siham A.
Kamal, Sali
Ali, Alya Abbas
Rashid, Layla
Source
Egyptian Pediatric Association Gazette
Issue
Vol. 66, Issue 1 (31 Mar. 2018), pp.28-34, 7 p.
Publisher
Egyptian Pediatric Association
Publication Date
2018-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Several studies proved the anti-inflammatory role of erythropoietin.
Little is known about the anti-inflammatory role of lymphotoxin alpha (LT-a).
This study was designed to investigate the patterns of erythropoietin (EPO) and LT-a levels in children with acute critical illness.
Patients and methods : Thirty-two critically ill children were prospectively subjected to serial estimation of EPO and LT-a levels, during the first 10 days of admission to one of the pediatric intensive care unit of Cairo University.
Thirteen healthy children served as control.
Results : Serial EPO and LT-a measurements showed significant increases over time early in their critical illness (P < 0.001, respectively).
Both cytokines showed significant increases in survivors (P < 0.001, respectively).
Kaplan Meier survival analysis revealed a significant increase in mortality with LT-a levels below 108.7 pg/ml, (P < 0.01) on admission.
However, EPO did not show any significant difference between survivors and non-survivors.
For both LT-a and EPO, levels at day 1 showed a significant decrease in septic patients.
EPO levels were significantly elevated on day 1 of admission in non-anemic [mean hemoglobin level (11.8 ± 0.9) g/dL, mean EPO level (110.85 ± 44.5) mIU/ml] compared with anemic patients [mean hemoglobin level (9.3 ± 1.3) g/dL, mean EPO level (69.84 ± 30.763) mIU/ml], 95% CI [13.896–68.112], P < (0.01).
Conclusions : Both EPO and LT-a showed significant increment in critically ill children especially in survivors.
Our data strongly suggest that, LT-a may have an anti-inflammatory role in children with acute critical illness.
American Psychological Association (APA)
al-Shirbini, Siham A.& Ali, Alya Abbas& Kamal, Sali& Marzuq, Huda& Rashid, Layla. 2018. Promising roles of erythropoietin and lymphotoxin alpha in critical illness : a pilot study in critically ill children. Egyptian Pediatric Association Gazette،Vol. 66, no. 1, pp.28-34.
https://search.emarefa.net/detail/BIM-783241
Modern Language Association (MLA)
al-Shirbini, Siham A.…[et al.]. Promising roles of erythropoietin and lymphotoxin alpha in critical illness : a pilot study in critically ill children. Egyptian Pediatric Association Gazette Vol. 66, no. 1 (Mar. 2018), pp.28-34.
https://search.emarefa.net/detail/BIM-783241
American Medical Association (AMA)
al-Shirbini, Siham A.& Ali, Alya Abbas& Kamal, Sali& Marzuq, Huda& Rashid, Layla. Promising roles of erythropoietin and lymphotoxin alpha in critical illness : a pilot study in critically ill children. Egyptian Pediatric Association Gazette. 2018. Vol. 66, no. 1, pp.28-34.
https://search.emarefa.net/detail/BIM-783241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 33-34
Record ID
BIM-783241