Correlation between vitamin D receptor gene polymorphisms and levels of some hormones in Iraqi infertile women with polycystic ovary syndrome
Joint Authors
Abd al-Hasan, Ismail Abd al-Rida
Kazim, Sana Jasim
Source
Iraqi Journal of Biotechnology
Issue
Vol. 16, Issue 4 (31 Dec. 2017), pp.104-113, 10 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
The polycystic ovary syndrome (PCOS) is a disorder that characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphologic features.
As defined by the diagnostic criteria of the National Institutes of Health (i.e., hyperandrogenism plus ovulatory dysfunction).
The purpose of this study was to investigate the correlation between VDR gene polymorphisms and level of LH, FSH, TSH and Prolactin hormones .This study was carried out in the Institute of Genetic Engineering and Biotechnology for Postgraduate Studies - University of Baghdad through the period from November 2016 - August 2017, The PCOS patients were taken from the Kamal Al-Samarraee Infertility Treatment Hospital in Baghdad.Women with PCOS (n=50) and apparently healthy control group (n=50) , were enrolled .
Genotyping of VDR gene (rs2228570) (rs7975232) , as well as (rs731236) SNPS between groups were determined by using Taqman genotyping assay .
Hormonal analysis for LH, FSH, TSH and Prolactin was performed by using Automated Immune Assay (AIA).
the results of the present study indicate that serum LH , FSH and TSH concentrations were unaffected by the studied SNPs of VDR gene within carriers of genotypes of rs2228570 , rs7975232 and rs731236 SNPs in VDR gene, while serum prolactin levels were significantly (p<0.05) higher in PCOS patients versus controls.
American Psychological Association (APA)
Kazim, Sana Jasim& Abd al-Hasan, Ismail Abd al-Rida. 2017. Correlation between vitamin D receptor gene polymorphisms and levels of some hormones in Iraqi infertile women with polycystic ovary syndrome. Iraqi Journal of Biotechnology،Vol. 16, no. 4, pp.104-113.
https://search.emarefa.net/detail/BIM-811034
Modern Language Association (MLA)
Kazim, Sana Jasim& Abd al-Hasan, Ismail Abd al-Rida. Correlation between vitamin D receptor gene polymorphisms and levels of some hormones in Iraqi infertile women with polycystic ovary syndrome. Iraqi Journal of Biotechnology Vol. 16, no. 4 (2017), pp.104-113.
https://search.emarefa.net/detail/BIM-811034
American Medical Association (AMA)
Kazim, Sana Jasim& Abd al-Hasan, Ismail Abd al-Rida. Correlation between vitamin D receptor gene polymorphisms and levels of some hormones in Iraqi infertile women with polycystic ovary syndrome. Iraqi Journal of Biotechnology. 2017. Vol. 16, no. 4, pp.104-113.
https://search.emarefa.net/detail/BIM-811034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 111-113
Record ID
BIM-811034