Immune profile in aborted Iraqi women with toxoplasmosis

Abstract EN

Background : Toxoplasmosis is one of the most important causes for abortion in women.

The immune responses have a role in the outcome of such infection in gestated women.

Aim : The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis.

Materials and Methods : Fifty-five aborted women and 29 healthy control women were enrolled in this study.

Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-ɣ), and IL-6.

Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma.

Results : Serum levels of IL-8 showed significant elevation, while IL-6 and INF-ɣ showed significant dropping in infected women compared to control.

Other immune factors showed nonsignificant differences between the two groups of the present study.

Conclusion : Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication.