Synthesis, characterization and biological activates studies of some new derivatives from 2-aminoo-5-mercapto-1, 3, 4-thiadiazole
Other Title(s)
تحضير، تشخيص و دراسة الفعالية البايولوجية لمشتقات جديدة للمركب2- امينو -5- مركبتو-1، 3، 4-ثاديازول
Joint Authors
Aday, Sahar Thamir
al-Khafaji, Zaynab Haytham Kazim
al-Zubaydi, Shadha Fadil
Hasan, Iman Mahdi Muhammad
Source
Issue
Vol. 15, Issue 1 (31 Mar. 2018), pp.48-56, 9 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2018-03-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5- mercapto-1, 3, 4-thiadiazole) as a starting material base.
The main heterocyclic compounds (1, 3, 4- thiadiazole, oxazole) etc, 2-amino-5-mercapto-1,3,4-thiadiazole compound (1) was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and carbon disulfide.
Oxidation of (1) via hydrogen peroxide, to have (2) which was treated with chloro acetyl chloride to get (3).
Preparation of thiazole ring (4) was from reacting of (3) with thiourea.
Synthesis of diazonium salts (5) from compound (4) using sodium nitrite and HCl.
Compound (5) reacted with different ester compounds to prepare a new azo compounds (6–8).Compound (3) reacts with viruses secondary amine to prepare compound (9–11).
Full characterization of the synthesized compounds was done by using spectroscopic analysis such as FT-IR, 1HNMR and C.H.N.S.
technique
American Psychological Association (APA)
al-Zubaydi, Shadha Fadil& al-Khafaji, Zaynab Haytham Kazim& Hasan, Iman Mahdi Muhammad& Aday, Sahar Thamir. 2018. Synthesis, characterization and biological activates studies of some new derivatives from 2-aminoo-5-mercapto-1, 3, 4-thiadiazole. Baghdad Science Journal،Vol. 15, no. 1, pp.48-56.
https://search.emarefa.net/detail/BIM-834155
Modern Language Association (MLA)
al-Zubaydi, Shadha Fadil…[et al.]. Synthesis, characterization and biological activates studies of some new derivatives from 2-aminoo-5-mercapto-1, 3, 4-thiadiazole. Baghdad Science Journal Vol. 15, no. 1 (2018), pp.48-56.
https://search.emarefa.net/detail/BIM-834155
American Medical Association (AMA)
al-Zubaydi, Shadha Fadil& al-Khafaji, Zaynab Haytham Kazim& Hasan, Iman Mahdi Muhammad& Aday, Sahar Thamir. Synthesis, characterization and biological activates studies of some new derivatives from 2-aminoo-5-mercapto-1, 3, 4-thiadiazole. Baghdad Science Journal. 2018. Vol. 15, no. 1, pp.48-56.
https://search.emarefa.net/detail/BIM-834155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 55-56
Record ID
BIM-834155