Synthesis, characterization and biological activates studies of some new derivatives from 2-aminoo-5-mercapto-1, 3, 4-thiadiazole

Other Title(s)

تحضير، تشخيص و دراسة الفعالية البايولوجية لمشتقات جديدة للمركب2- امينو -5- مركبتو-1، 3، 4-ثاديازول

Joint Authors

Aday, Sahar Thamir
al-Khafaji, Zaynab Haytham Kazim
al-Zubaydi, Shadha Fadil
Hasan, Iman Mahdi Muhammad

Source

Baghdad Science Journal

Issue

Vol. 15, Issue 1 (31 Mar. 2018), pp.48-56, 9 p.

Publisher

University of Baghdad College of Science for Women

Publication Date

2018-03-31

Country of Publication

Iraq

No. of Pages

9

Main Subjects

Natural & Life Sciences (Multidisciplinary)

Abstract EN

In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5- mercapto-1, 3, 4-thiadiazole) as a starting material base.

The main heterocyclic compounds (1, 3, 4- thiadiazole, oxazole) etc, 2-amino-5-mercapto-1,3,4-thiadiazole compound (1) was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and carbon disulfide.

Oxidation of (1) via hydrogen peroxide, to have (2) which was treated with chloro acetyl chloride to get (3).

Preparation of thiazole ring (4) was from reacting of (3) with thiourea.

Synthesis of diazonium salts (5) from compound (4) using sodium nitrite and HCl.

Compound (5) reacted with different ester compounds to prepare a new azo compounds (6–8).Compound (3) reacts with viruses secondary amine to prepare compound (9–11).

Full characterization of the synthesized compounds was done by using spectroscopic analysis such as FT-IR, 1HNMR and C.H.N.S.

technique

American Psychological Association (APA)

al-Zubaydi, Shadha Fadil& al-Khafaji, Zaynab Haytham Kazim& Hasan, Iman Mahdi Muhammad& Aday, Sahar Thamir. 2018. Synthesis, characterization and biological activates studies of some new derivatives from 2-aminoo-5-mercapto-1, 3, 4-thiadiazole. Baghdad Science Journal،Vol. 15, no. 1, pp.48-56.
https://search.emarefa.net/detail/BIM-834155

Modern Language Association (MLA)

al-Zubaydi, Shadha Fadil…[et al.]. Synthesis, characterization and biological activates studies of some new derivatives from 2-aminoo-5-mercapto-1, 3, 4-thiadiazole. Baghdad Science Journal Vol. 15, no. 1 (2018), pp.48-56.
https://search.emarefa.net/detail/BIM-834155

American Medical Association (AMA)

al-Zubaydi, Shadha Fadil& al-Khafaji, Zaynab Haytham Kazim& Hasan, Iman Mahdi Muhammad& Aday, Sahar Thamir. Synthesis, characterization and biological activates studies of some new derivatives from 2-aminoo-5-mercapto-1, 3, 4-thiadiazole. Baghdad Science Journal. 2018. Vol. 15, no. 1, pp.48-56.
https://search.emarefa.net/detail/BIM-834155

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 55-56

Record ID

BIM-834155