Efficacy and bioavailability of silymarin on plasma S100B level in cardiotoxicity-induced rats

Dissertant

Khalil, Diyar Majid Jalil

Thesis advisor

al-Tai, Taghrid

University

Isra University

Faculty

Faculty of Pharmacy

University Country

Jordan

Degree

Master

Degree Date

2019

English Abstract

Silymarin is the main extract from the seeds of Milk thistle (Silybum marianum) and contains approximately 65–80% of silymarin flavonolignans compounds.

The major component of the silymarin complex is silibinin.

Cardiovascular toxicity is the leading cause of death associated with drugs overdose.

The calcium (Ca2+)-binding protein S100B is a multifunctional protein primarily expressed by the brain and myocardial tissues, through its interaction with several effector proteins within cells have involved in the regulation of a variety of cellular processes such as protection from oxidative cell damage.

This study was designed to investigate the cardioprotective effect of silymarin on clozapine-induced cardiotoxicity in albino Wistar rats.

The heart damage was indicated by elevated levels of the plasma biomarkers such as S100B, troponin, and creatine kinase-MB (CK-MB).

S100B levels were correlated with cardiovascular toxic effects induced by clozapine in a rat model.

Main Topic

Pharmacology

No. of Pages

103

Table of Contents

• APA
• MLA
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Language

English

Data Type

Arab Theses

Record ID

BIM-895746