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Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats
Other Title(s)
بعض الصفات المضادة للسكري لمستخلصات Prosopis farcta في الجرذان البالغة المستحدث فيها السكري بالألوكسان
Joint Authors
Muhammad, Ismail Hasan
Kaki, Ismail Salih
Farimani, Mahdi Moridi
Source
Iraqi Journal of Veterinary Sciences
Issue
Vol. 34, Issue 1 (30 Jun. 2020), pp.109-113, 5 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2020-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Prosopis farcta is belonged to Mimosaceae family, commonly known as mesquite.
It was chosen to investigate their effect on α-glucosidase inhibitory activity (in-vitro), serum glucose and liver functions.
Roots, fruits, and leaves of P.
farcta, were extracted by n-hexane, ethyl acetate, and methanol.
α-glucosidase inhibition was analyzed by using ELISA technique then half maximal inhibitory concentration IC50 was found.
The blood glucose levels were determined with a glucose analyzer model.
The serum alkaline phosphatase (ALP), Alanine transaminase (ALT), aspartate aminotransferase (AST) and serum total bilirubin (TB) were estimated by using the Cobas diagnostic kit with a fully automated chemical analyzer.
Diabetes was done by a single dose of 120 mg alloxan/kg b.w with subcutaneously injection.
Ethyl acetate extracts of P.
farcta showed the higher α-glucosidase inhibitory activity, and the best one was root extract.
Treatments of the alloxan-induced diabetes rats were done by daily oral administration of different concentrations with P.
farcta extracts of ethyl acetate for 28 days and the dose 200 mg/kg BW was the effective one.
The root extract was the best one for reduction of serum glucose followed by leaves then fruits.
Administration of root extract of P.
farcta showed a decrease in the levels of ALP and TB in alloxan-induced diabetes rats.
The fruit extract of P.
farcta showed decreasing in the level of ALP in alloxan-induced diabetes rats.
In conclusion, the P.
farcta extracts for ethyl acetate have properties of hypoglycemic effect as well as improving some parameters related with diabetic complications of liver functions.
American Psychological Association (APA)
Muhammad, Ismail Hasan& Kaki, Ismail Salih& Farimani, Mahdi Moridi. 2020. Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats. Iraqi Journal of Veterinary Sciences،Vol. 34, no. 1, pp.109-113.
https://search.emarefa.net/detail/BIM-948795
Modern Language Association (MLA)
Muhammad, Ismail Hasan…[et al.]. Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats. Iraqi Journal of Veterinary Sciences Vol. 34, no. 1 (2020), pp.109-113.
https://search.emarefa.net/detail/BIM-948795
American Medical Association (AMA)
Muhammad, Ismail Hasan& Kaki, Ismail Salih& Farimani, Mahdi Moridi. Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats. Iraqi Journal of Veterinary Sciences. 2020. Vol. 34, no. 1, pp.109-113.
https://search.emarefa.net/detail/BIM-948795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 113
Record ID
BIM-948795