Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β
Joint Authors
Luo, Liang
Lv, Tangfeng
Wang, Qian
Zhang, Ting
Gu, Xiaoling
Xu, Feng
Song, Yong
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study investigated the relationship between antiapoptotic activities induced by activated protein C and endoplasmic reticulum stress.
In this study, it was observed that activated protein C elicited a rise in glucose-regulated protein 78 and glycogen synthase kinase-3β and inhibited apoptosis in human umbilical vein endothelial cells induced by lipopolysaccharide.
Calcium inhibition did not alter the antiapoptotic effect of activated protein C.
The antiapoptotic efficiency of activated protein C was reduced in human umbilical vein endothelial cells following treatment with glycogen synthase kinase-3β-siRNA.
In summary, activated protein C induced endoplasmic reticulum stress and attenuated lipopolysaccharide-induced human umbilical vein endothelial cell apoptosis mediated by glycogen synthase kinase-3β.
American Psychological Association (APA)
Luo, Liang& Lv, Tangfeng& Wang, Qian& Zhang, Ting& Gu, Xiaoling& Xu, Feng…[et al.]. 2012. Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1001153
Modern Language Association (MLA)
Luo, Liang…[et al.]. Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1001153
American Medical Association (AMA)
Luo, Liang& Lv, Tangfeng& Wang, Qian& Zhang, Ting& Gu, Xiaoling& Xu, Feng…[et al.]. Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1001153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001153
